Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran.
Iranian Society for Support of Patients With Infectious Disease, Tehran, Iran.
J Prim Care Community Health. 2024 Jan-Dec;15:21501319241251941. doi: 10.1177/21501319241251941.
In this era in which the vast majority of the global population have developed COVID-19 infection and/or got vaccinated against it, identification of the late disorders as the vaccines' side effect or long-COVID manifestation seems essential. This study included the vaccinated individuals of 4 different vaccine regimens including inactivated virus-based, subunit protein, and adenovirus-based vaccines in a follow-up schedule 6-month post the booster shot. All the documented vaccine adverse events were thoroughly assessed considering the cases' medical history by Adverse Events Committee of Pasteur Institute of Iran. Totally 329 individuals who got 3 doses of vaccination were followed 6 months after the booster shots among whom 41 (12.4%) cases with the mean age of 40.9 ± 10.48 years had a type of disorder. Gynecological and osteoarticular involvements were the most common recorded disorders of which 73.1% were possibly linked to vaccination outcomes and the rest were affected by both long-COVID-19 and vaccination. Notably, the average time of symptoms persistence was 155 ± 10.4 days. This study has the advantage of long-term follow-up which presents various forms of late events in each episode of COVID-19 infection and vaccination. About 26.8% of people with persistent complications suffered from both long-COVOD/ vaccination in whom the differentiation between the vaccine side effect and long-COVID manifestation was quite challenging. Long-term follow-up studies in large population seems essential to outline the role of long-COVID and vaccination regarding persistent complications.
在这个全球绝大多数人都感染了 COVID-19 或接种了疫苗的时代，识别这些晚期疾病是疫苗的副作用还是长新冠的表现似乎至关重要。本研究纳入了 4 种不同疫苗方案的接种者，包括灭活病毒疫苗、亚单位蛋白疫苗和腺病毒疫苗，在加强针接种后进行了 6 个月的随访。伊朗巴斯德研究所的不良事件委员会对所有有记录的疫苗不良事件进行了彻底评估，同时考虑了病例的病史。在加强针接种后 6 个月，共有 329 名接种了 3 剂疫苗的人接受了随访，其中 41 例（12.4%）年龄为 40.9±10.48 岁的患者出现了某种类型的疾病。妇科和骨关节炎受累是最常见的记录疾病，其中 73.1%可能与疫苗结果有关，其余则受长新冠和疫苗的双重影响。值得注意的是，症状持续时间的平均时间为 155±10.4 天。本研究的优势在于长期随访，可以在每一次 COVID-19 感染和疫苗接种中呈现出各种形式的晚期事件。约 26.8%的持续性并发症患者同时患有长新冠/疫苗接种，区分疫苗副作用和长新冠表现具有挑战性。在大人群中进行长期随访研究对于阐明长新冠和疫苗接种在持续性并发症中的作用至关重要。
