Loft Josefine Amalie, Riis Peter Theut, Schultz Nicolai Aagaard, Bjerrum Stephanie, Schønning Kristian, Pedersen Christian Ross, Krohn Paul Suno, Nielsen Susanne Dam
Afdeling for Infektionssygdomme, Københavns Universitetshospital - Rigshospitalet.
Dermato-Venerologisk Afdeling og Videncenter for Sårheling, Københavns Universitetshospital - Bispebjerg Hospital.
Ugeskr Laeger. 2024 Apr 8;186(15):V11230726. doi: 10.61409/V11230726.
Cytomegalovirus infection (CMV) can be fatal for organ transplant recipients as shown in this case report. Maribavir is a recently approved drug, which can be used for therapy-refractory CMV infection or when other treatment options cannot be used. The patient in this case report was a CMV-infected liver transplant recipient, who developed a severe erythema and high CMV DNA during valganciclovir therapy. Toxic epidermal necrolysis was suspected. The patient was treated with maribavir, and both CMV DNA and the skin normalised. This case illustrates that maribavir is a useful alternative to other antiviral drugs for CMV infection.
如本病例报告所示,巨细胞病毒感染(CMV)对器官移植受者可能是致命的。马里巴韦是一种最近获批的药物,可用于治疗难治性CMV感染或无法使用其他治疗方案的情况。本病例报告中的患者是一名CMV感染的肝移植受者,在缬更昔洛韦治疗期间出现严重红斑和高CMV DNA水平。怀疑为中毒性表皮坏死松解症。该患者接受了马里巴韦治疗,CMV DNA和皮肤均恢复正常。本病例表明,对于CMV感染,马里巴韦是其他抗病毒药物的一种有用替代药物。