School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
J Microencapsul. 2024 Jun;41(4):296-311. doi: 10.1080/02652048.2024.2348450. Epub 2024 May 6.
To construct the microemulsion delivery system (ME) loading ATSO and NA and study their physicochemical characteristics to enhance their stability and water solubility.
By plotting ternary phase diagrams, the composition and proportions of the MEs were determined. The physicochemical characteristics and stability of MEs were evaluated by mean diameter, polydispersity index (PDI), pH, electrical conductivity, transmission electron microscopy (TEM), rheological behaviour measurement, and phase inversion temperature (PIT).
The MEs was composed with EL-40 as a surfactant and specifically with the addition of ethanol as a cosurfactant in NA-loaded ME. The mean diameters of ATSO-loaded ME and NA-loaded ME were 39.65 ± 0.24 nm and 32.90 ± 2.65 nm, and PDI were 0.49 ± 0.01 and 0.28 ± 0.14, respectively. The TEM confirmed the spherical and smooth morphology of MEs. The rheological results indicated that MEs are dilatant fluids with the advantages of low viscosity, high fluidity, and tolerance to temperature fluctuations. The mean diameter and PDI of MEs showed no significant change after storage at 25 °C for 28 days and centrifugation.
The prepared microemulsions could expand the application prospects of ATSO and NA products in cosmetics, medicine, foods and other fields.
构建载有 ATSO 和 NA 的微乳传递系统（ME），并研究其理化特性，以提高其稳定性和水溶性。
通过绘制三元相图，确定 ME 的组成和比例。通过平均粒径、多分散指数（PDI）、pH 值、电导率、透射电子显微镜（TEM）、流变行为测量和相转变温度（PIT）评估 ME 的理化特性和稳定性。
ME 由 EL-40 作为表面活性剂和特定的乙醇作为助表面活性剂组成，在载有 NA 的 ME 中。ATSO 载 ME 和 NA 载 ME 的平均粒径分别为 39.65±0.24nm 和 32.90±2.65nm，PDI 分别为 0.49±0.01 和 0.28±0.14。TEM 证实了 ME 的球形和光滑形态。流变学结果表明，ME 是膨胀性流体，具有低粘度、高流动性和耐受温度波动的优点。在 25°C 下储存 28 天和离心后，ME 的平均粒径和 PDI 没有明显变化。
所制备的微乳可以扩大 ATOS 和 NA 产品在化妆品、医药、食品等领域的应用前景。
