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利用疟疾疫苗和 mRNA 技术解决全球制药研发和生产中的不平等问题,以实现疾病消除。

Leveraging malaria vaccines and mRNA technology to tackle the global inequity in pharmaceutical research and production towards disease elimination.

机构信息

Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.

出版信息

Malar J. 2024 May 6;23(1):136. doi: 10.1186/s12936-024-04972-5.

DOI:10.1186/s12936-024-04972-5
PMID:38711053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11075248/
Abstract

Malaria vaccine introduction in endemic countries is a game-changing milestone in the fight against the disease. This article examines the inequity in the global pharmaceutical research, development, manufacturing, and trade landscape. The role of inequity in hindering progress towards malaria elimination is explored. The analysis finds that transformational changes are required to create an equity-enabling environment. Addressing the inequity is critical to maximizing the public health impact of vaccines and attaining sustainability. Avenues to catalyze progress by leveraging malaria vaccines and messenger ribonucleic acid (mRNA) technology are discussed.

摘要

疟疾疫苗在流行国家的引入是对抗该疾病的一个具有变革意义的里程碑。本文探讨了在全球制药研发、制造和贸易格局中存在的不平等现象。分析发现,需要进行变革性的改变,以创造一个有利于公平的环境。解决不平等问题对于最大限度地发挥疫苗的公共卫生影响和实现可持续性至关重要。本文还讨论了利用疟疾疫苗和信使核糖核酸(mRNA)技术来推动进展的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f4b/11075248/4771d33d980e/12936_2024_4972_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f4b/11075248/30d7908ece10/12936_2024_4972_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f4b/11075248/4771d33d980e/12936_2024_4972_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f4b/11075248/30d7908ece10/12936_2024_4972_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f4b/11075248/4771d33d980e/12936_2024_4972_Fig2_HTML.jpg

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本文引用的文献

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Malaria vaccination: hurdles to reach high-risk children.疟疾疫苗接种:为高危儿童接种疫苗面临的障碍。
BMC Med. 2024 Mar 13;22(1):111. doi: 10.1186/s12916-024-03321-2.
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Corruption risks in health procurement during the COVID-19 pandemic and anti-corruption, transparency and accountability (ACTA) mechanisms to reduce these risks: a rapid review.新冠肺炎大流行期间卫生采购中的腐败风险,以及减少这些风险的反腐败、透明度和问责制(ACTA)机制:快速审查。
Global Health. 2023 Nov 24;19(1):91. doi: 10.1186/s12992-023-00994-x.
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Modeling of malaria vaccine effectiveness on disease burden and drug resistance in 42 African countries.
42个非洲国家疟疾疫苗效力对疾病负担及耐药性的建模分析
Commun Med (Lond). 2023 Oct 13;3(1):144. doi: 10.1038/s43856-023-00373-y.
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Building Africa's first mRNA vaccine facility.建设非洲首个信使核糖核酸疫苗生产设施。
Lancet. 2023 Jul 22;402(10398):287-288. doi: 10.1016/S0140-6736(23)01119-4.
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mRNA vaccine against malaria tailored for liver-resident memory T cells.针对肝脏驻留记忆 T 细胞的疟疾 mRNA 疫苗。
Nat Immunol. 2023 Sep;24(9):1487-1498. doi: 10.1038/s41590-023-01562-6. Epub 2023 Jul 20.
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The economic costs of malaria in pregnancy: evidence from four sub-Saharan countries.孕期疟疾的经济成本:来自撒哈拉以南四个国家的证据。
Gates Open Res. 2023 May 5;7:47. doi: 10.12688/gatesopenres.14375.2. eCollection 2023.
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Trop Med Health. 2023 May 17;51(1):29. doi: 10.1186/s41182-023-00516-w.
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