Department of Cosmetic Laser Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Lasers Surg Med. 2024 Jul;56(5):437-445. doi: 10.1002/lsm.23795. Epub 2024 May 6.
The picosecond alexandrite laser has been safely and effectively used to treat the nevus of Ota in adults. However, limited data are available for children.
To investigate the efficacy, safety, and correlative influencing factors of a 755nm picosecond alexandrite laser in the treatment of nevus of Ota in children.
We retrospectively analyzed Chinese children with nevus of Ota who received a 755nm picosecond alexandrite laser treatment in a tertiary dermatological hospital.
A total of 305 pediatric patients received an average of two treatments achieving an average of 79% pigment clearance. After the first treatment, 22 patients achieved complete clearance (95%-100%), and 72 patients achieved excellent response (75%-94%), with an average initial efficacy of 63% lesion clearance. Treatment at an early age achieved better initial efficacy (0- to 12-month group >1- to 6-year group, 6- to 12-year group). And 0- to 12-month group achieved better final efficacy. More treatment sessions also increased the final efficacy. Both initial efficacy and final efficacy were better when treating a darker lesion. The incidence of complications was 12.1%, with 10.8% being post-inflammatory hyperpigmentation and 1.3% being hypopigmentation. The rate of recurrence was 6.6%.
Retrospective study.
A 755nm picosecond alexandrite laser is safe and effective in treating nevus of Ota in children. Younger to initiate treatment, darker lesions, and more treatments are positively associated with better pigmentation clearance.
皮秒翠绿宝石激光已被安全有效地用于治疗成人太田痣。然而，儿童的相关数据有限。
探讨 755nm 皮秒翠绿宝石激光治疗儿童太田痣的疗效、安全性及相关影响因素。
我们回顾性分析了在一家三级皮肤科医院接受 755nm 皮秒翠绿宝石激光治疗的中国儿童太田痣患者。
共有 305 名儿科患者接受了平均两次治疗，平均色素清除率达到 79%。首次治疗后，22 例患者完全清除（95%-100%），72 例患者获得良好反应（75%-94%），平均初始疗效为 63%的皮损清除率。早期治疗的初始疗效更好（0-12 月龄组＞1-6 岁组、6-12 岁组），0-12 月龄组的最终疗效更好。接受更多治疗次数也会提高最终疗效。初始疗效和最终疗效均与皮损颜色更深呈正相关。并发症发生率为 12.1%，其中 10.8%为炎症后色素沉着过度，1.3%为色素减退。复发率为 6.6%。
回顾性研究。
755nm 皮秒翠绿宝石激光治疗儿童太田痣安全有效。早期治疗、颜色更深的皮损、更多治疗次数与更好的色素清除率呈正相关。
