Kiselev Artem, Park Sangbum
Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, United States.
Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, United States.
Front Physiol. 2024 Apr 22;15:1397067. doi: 10.3389/fphys.2024.1397067. eCollection 2024.
The hair follicle is a dynamic mini-organ that has specialized cycles and architectures with diverse cell types to form hairs. Previous studies for several decades have investigated morphogenesis and signaling pathways during embryonic development and adult hair cycles in both mouse and human skin. In particular, hair follicle stem cells and mesenchymal niches received major attention as key players, and their roles and interactions were heavily revealed. Although resident and circulating immune cells affect cellular function and interactions in the skin, research on immune cells has mainly received attention on diseases rather than development or homeostasis. Recently, many studies have suggested the functional roles of diverse immune cells as a niche for hair follicles. Here, we will review recent findings about immune niches for hair follicles and provide insight into mechanisms of hair growth and diseases.
毛囊是一个动态的微型器官，具有特殊的周期和结构，包含多种细胞类型以形成毛发。几十年来，先前的研究已经在小鼠和人类皮肤中研究了胚胎发育和成年毛发周期中的形态发生和信号通路。特别是，毛囊干细胞和间充质微环境作为关键参与者受到了主要关注，并且它们的作用和相互作用也得到了充分揭示。尽管驻留和循环免疫细胞会影响皮肤中的细胞功能和相互作用，但对免疫细胞的研究主要集中在疾病方面，而非发育或稳态。最近，许多研究表明多种免疫细胞作为毛囊微环境具有功能作用。在此，我们将综述关于毛囊免疫微环境的最新发现，并深入探讨毛发生长和疾病的机制。
