Park Sangbum
Institute for Quantitative Health Science & Engineering (IQ), Michigan State University, East Lansing, MI, United States.
Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, United States.
Front Cell Dev Biol. 2022 Jul 22;10:933370. doi: 10.3389/fcell.2022.933370. eCollection 2022.
Hair follicles are mini organs that repeat the growth and regression cycle continuously. These dynamic changes are driven by the regulation of stem cells via their multiple niche components. To build the complex structure of hair follicles and surrounding niches, sophisticated morphogenesis is required during embryonic development. This review will explore how hair follicles are formed and maintained through dynamic cellular changes and diverse signaling pathways. In addition, comparison of differences in stem cells and surrounding niche components during embryogenesis, neogenesis, and organogenesis will provide a comprehensive understanding of mechanisms for hair follicle generation and insights into skin regeneration.
毛囊是不断重复生长和退化周期的微型器官。这些动态变化是由干细胞通过其多种微环境成分的调节驱动的。为了构建毛囊及其周围微环境的复杂结构，胚胎发育过程中需要精密的形态发生。本综述将探讨毛囊如何通过动态细胞变化和多样的信号通路形成并维持。此外，比较胚胎发生、新生和器官发生过程中干细胞及周围微环境成分的差异，将有助于全面理解毛囊生成的机制，并深入了解皮肤再生。
