Cao Ying, Huang Yao, Chen Xianglong, Wang Wei, Chen Huifang, Yin Ting, Nickel Dominik, Li Changchun, Shao Junhua, Zhang Shi, Wang Xiaoxia, Zhang Jiuquan
School of Medicine, Chongqing University, Chongqing, China.
Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), Chongqing, China.
Insights Imaging. 2024 May 7;15(1):112. doi: 10.1186/s13244-024-01697-6.
To determine the optimal scan duration for ultrafast DCE-MRI in effectively differentiating benign from malignant breast lesions.
The study prospectively recruited participants who underwent breast ultrafast DCE-MRI from September 2021 to March 2023. A 30-phase breast ultrafast DCE-MRI on a 3.0-T MRI system was conducted with a 4.5-s temporal resolution. Scan durations ranged from 40.5 s to 135.0 s, during which the analysis is performed at three-phase intervals, forming eight dynamic sets (scan duration [SD]: 40.5 s, SD: 54.0 s, SD: 67.5 s, SD: 81.0 s, SD: 94.5 s, SD: 108.0 s, SD: 121.5 s, and SD: 135.0 s). Two ultrafast DCE-MRI parameters, maximum slope (MS) and initial area under the curve in 60 s (iAUC), were calculated for each dynamic set and compared between benign and malignant lesions. Areas under the receiver operating characteristic curve (AUCs) were used to assess their diagnostic performance.
A total of 140 women (mean age, 47 ± 11 years) with 151 lesions were included. MS and iAUC from eight dynamic sets exhibited significant differences between benign and malignant lesions (all p < 0.05), except iAUC at SD. The AUC of MS (AUC = 0.804) and iAUC (AUC = 0.659) at SD were significantly higher than their values at SD (AUC = 0.606 and 0.516; corrected p < 0.05). No significant differences in AUCs for MS and iAUC were observed from SD to SD (all corrected p > 0.05).
Ultrafast DCE-MRI with a 67.5-s scan duration appears optimal for effectively differentiating malignant from benign breast lesions.
By evaluating scan durations (40.5-135 s) and analyzing two ultrafast DCE-MRI parameters, we found a scan duration of 67.5 s optimal for discriminating between these lesions and offering a balance between acquisition time and diagnostic efficacy.
Ultrafast DCE-MRI can effectively differentiate malignant from benign breast lesions. A minimum of 67.5-sec ultrafast DCE-MRI scan duration is required to differentiate benign and malignant lesions. Extending the scan duration beyond 67.5 s did not significantly improve diagnostic accuracy.
确定在有效鉴别乳腺良恶性病变方面，超快动态对比增强磁共振成像（DCE-MRI）的最佳扫描时长。
本研究前瞻性招募了2021年9月至2023年3月期间接受乳腺超快DCE-MRI检查的参与者。在3.0-T磁共振成像系统上进行了30期乳腺超快DCE-MRI检查，时间分辨率为4.5秒。扫描时长从40.5秒到135.0秒不等，在此期间以三期为间隔进行分析，形成八个动态数据集（扫描时长[SD]：40.5秒、SD：54.0秒、SD：67.5秒、SD：81.0秒、SD：94.5秒、SD：108.0秒、SD：121.5秒和SD：135.0秒）。为每个动态数据集计算两个超快DCE-MRI参数，即最大斜率（MS）和60秒内的初始曲线下面积（iAUC），并在良性和恶性病变之间进行比较。采用受试者工作特征曲线下面积（AUC）评估其诊断性能。
共纳入140名女性（平均年龄47±11岁），有151个病变。除了在特定扫描时长下的iAUC外，八个动态数据集的MS和iAUC在良性和恶性病变之间存在显著差异（所有p<0.05）。特定扫描时长下MS的AUC（AUC=0.804）和iAUC（AUC=0.659）显著高于其他扫描时长下的值（AUC=0.606和0.516；校正p<0.05）。从一个扫描时长到另一个扫描时长，MS和iAUC 的AUC没有观察到显著差异（所有校正p>0.05）。
扫描时长为67.5秒的超快DCE-MRI似乎最适合有效鉴别乳腺恶性和良性病变。
通过评估扫描时长（40.
