School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan 250117, China; Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, China.
School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan 250117, China.
Virus Res. 2024 Jul;345:199388. doi: 10.1016/j.virusres.2024.199388. Epub 2024 May 16.
Human enteroviruses (EVs) represent a global public health concern due to their association with a range of serious pediatric illnesses. Despite the high morbidity and mortality exerted by EVs, no broad-spectrum antivirals are currently available. Herein, we presented evidence that doxycycline can inhibit in vitro replication of various neurotropic EVs, including enterovirus A71 (EV-A71), enterovirus D68 (EV-D68), and coxsackievirus (CV)-A6, in a dose-dependent manner. Further investigations indicated that the drug primarily acted at the post-entry stage of virus infection in vitro, with inhibitory effects reaching up to 89 % for EV-A71 when administered two hours post-infection. These findings provide valuable insights for the development of antiviral drugs against EV infections.
人类肠道病毒（EVs）因其与一系列严重儿科疾病有关，因此成为全球公共卫生关注的焦点。尽管 EVs 会导致高发病率和死亡率，但目前尚无广谱抗病毒药物。在此，我们提供的证据表明，强力霉素可以以剂量依赖的方式抑制多种神经亲和性 EV 的体外复制，包括肠道病毒 A71（EV-A71）、肠道病毒 D68（EV-D68）和柯萨奇病毒（CV）-A6。进一步的研究表明，该药物主要在病毒感染的进入后阶段发挥作用，在感染后两小时给予强力霉素时，对 EV-A71 的抑制作用高达 89%。这些发现为开发针对 EV 感染的抗病毒药物提供了有价值的见解。
