苯噻啶对大鼠离体灌注胰腺胰岛素分泌的抑制作用。
Inhibition of insulin secretion from the perfused pancreas of the rat by pizotifen.
作者信息
Joost H G
出版信息
Br J Pharmacol. 1979 Oct;67(2):265-7. doi: 10.1111/j.1476-5381.1979.tb08675.x.
Abstract
1 In the perfused rat pancreas the effects of pizotifen on insulin release induced by 20 mM glucose were studied. 2 Pizotifen (10 and 100 muM) significantly reduced the insulin release during a 25 min perfusion period to 49% and 7% of the controls. 3 The same concentrations of the structurally related agents cyproheptadine, doxepin, and chlorpromazine produced a comparable inhibition.
摘要
在灌注大鼠胰腺中，研究了苯噻啶对20 mM葡萄糖诱导的胰岛素释放的影响。
苯噻啶（10和100 μM）在25分钟的灌注期内显著降低胰岛素释放，分别降至对照的49%和7%。
相同浓度的结构相关药物赛庚啶、多塞平和氯丙嗪产生了类似的抑制作用。
相似文献
1
Inhibition of insulin secretion from the perfused pancreas of the rat by pizotifen.苯噻啶对大鼠离体灌注胰腺胰岛素分泌的抑制作用。
Br J Pharmacol. 1979 Oct;67(2):265-7. doi: 10.1111/j.1476-5381.1979.tb08675.x.
2
Inhibition of insulin and glucagon release from the perfused rat pancreas by cyproheptadine (Periactinol, Nuran).赛庚啶（periactinol，Nuran）对灌注大鼠胰腺胰岛素和胰高血糖素释放的抑制作用
Diabetologia. 1976 Jul;12(3):201-6. doi: 10.1007/BF00422086.
3
Inhibition of insulin release from the rat pancreas by cyproheptadine and tricyclic antidepressants.赛庚啶和三环类抗抑郁药对大鼠胰腺胰岛素释放的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1974;285(1):99-102. doi: 10.1007/BF00499530.
4
Effects of cyproheptadine on insulin secretion by isolated perifused rat islets.赛庚啶对离体灌流大鼠胰岛胰岛素分泌的影响。
Diabetes. 1975 Sep;24(9):836-41. doi: 10.2337/diab.24.9.836.
5
Diltiazem inhibition of glucose-induced insulin secretion from the isolated perfused rat pancreas.
Eur J Pharmacol. 1988 Nov 8;156(3):415-7. doi: 10.1016/0014-2999(88)90288-9.
6
Proceedings: Inhibition of insulin release by cyproheptadine in vitro.论文集：赛庚啶在体外对胰岛素释放的抑制作用
Naunyn Schmiedebergs Arch Pharmacol. 1975;287 Suppl:R59.
7
Cyproheptadine and beta cell function in the rat: insulin secretion from pancreas segments in vitro.赛庚啶与大鼠β细胞功能：体外胰腺片段的胰岛素分泌
Proc Soc Exp Biol Med. 1975 Oct;150(1):1-6. doi: 10.3181/00379727-150-38961.
8
Effects of drugs on glucose and tolbutamide-stimulated insulin release from isolated rat islets of Langerhans.药物对从分离的大鼠胰岛释放的葡萄糖和甲苯磺丁脲刺激的胰岛素的影响。
Biochem Pharmacol. 1976 Jul 1;25(13):1451-4. doi: 10.1016/0006-2952(76)90059-9.
9
Requirement for calcium ion in insulin secretion by the perfused rat pancreas.灌注大鼠胰腺胰岛素分泌中钙离子的需求
Am J Physiol. 1968 Jan;214(1):174-8. doi: 10.1152/ajplegacy.1968.214.1.174.
10
Subcellular B cell calcium and insulin secretion in vitro. Comparative ultracytochemical studies after glucose stimulation and cyproheptadine inhibition.体外亚细胞水平B细胞钙与胰岛素分泌。葡萄糖刺激及赛庚啶抑制后的比较超微细胞化学研究
Virchows Arch A Pathol Anat Histol. 1978 Sep 7;379(3):203-17. doi: 10.1007/BF00432636.
本文引用的文献
1
EFFECTS OF CARBOHYDRATES ON SECRETION OF INSULIN FROM ISOLATED RAT PANCREAS.碳水化合物对离体大鼠胰腺胰岛素分泌的影响。
Am J Physiol. 1963 Oct;205:638-44. doi: 10.1152/ajplegacy.1963.205.4.638.
2
The effect of cyproheptadine on carbohydrate metabolism.赛庚啶对碳水化合物代谢的影响。
Clin Pharmacol Ther. 1966 May-Jun;7(3):340-6. doi: 10.1002/cpt196673340.
3
Studies of a simplified plasma insulin immunoassaay using cellulose powder.使用纤维素粉末的简化血浆胰岛素免疫测定法研究。
Diabetes. 1968 Jul;17(7):444-59. doi: 10.2337/diab.17.7.444.
4
The displacement of membrane calcium by a local anesthetic (chlorpromazine).局部麻醉药（氯丙嗪）对膜钙的置换作用。
Biochim Biophys Acta. 1969;193(2):338-49. doi: 10.1016/0005-2736(69)90194-1.
5
The significance of 5-hydroxytryptamine for insulin secretion in the mouse.
Horm Metab Res. 1971 Sep;3(5):305-9. doi: 10.1055/s-0028-1094131.
6
Effect of chlorpromazine (CPZ) on insulin release in vivo and in vitro in the rat.氯丙嗪（CPZ）对大鼠体内和体外胰岛素释放的影响。
J Pharmacol Exp Ther. 1973 Nov;187(2):423-9.
7
Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.苯噻啶（BC - 105）：其药理特性及对血管性头痛治疗效果的综述
Drugs. 1972;3(3):159-203. doi: 10.2165/00003495-197203030-00002.
8
The nature of the interaction of amines with the pancreatic beta cell to influence insulin secretion.
J Pharmacol Exp Ther. 1971 Oct;179(1):56-65.
9
[Effects of a serotonin antagonist (BC 105 Sandoz) on carbohydrate metabolism].
Rev Med Liege. 1970 Jul;25(13):414-21.
10
Comparative trial of serotonin antagonists in the management of migraine.5-羟色胺拮抗剂治疗偏头痛的对比试验
Br Med J. 1970 May 9;2(5705):327-30. doi: 10.1136/bmj.2.5705.327.
Zotero 插件