5-羟色胺拮抗剂治疗偏头痛的对比试验
Comparative trial of serotonin antagonists in the management of migraine.
作者信息
Lance J W, Anthony M, Somerville B
出版信息
Br Med J. 1970 May 9;2(5705):327-30. doi: 10.1136/bmj.2.5705.327.
Abstract
The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than "half improved." The corresponding figures for BC105 were 10% and 40%, respectively.The results with BC105 were significantly better than those with placebo (P<0.02). The total improvement rates with methdilazine (45%) and cyproheptadine (43%) were better than those with placebo (32%) but did not achieve statistical significance. A new preparation, methylergol carbamide maleate, which is chemically related to methysergide, did not give better results than placebo.
摘要
在290名随访期长达三年的患者中，比较了五种不同血清素拮抗剂预防偏头痛的效果。每日服用3 - 6毫克麦角酸二乙胺最为有效，20%的接受治疗患者不再头痛，另有44%的患者改善程度超过“一半”。BC105的相应数字分别为10%和40%。BC105的结果显著优于安慰剂（P<0.02）。美喹他嗪（45%）和赛庚啶（43%）的总体改善率优于安慰剂（32%），但未达到统计学显著性。一种与麦角酸二乙胺化学相关的新制剂马来酸甲基麦角酰胺，其效果并未优于安慰剂。
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