携带xid缺陷的小鼠中抗流感抗体的同型谱。
Isotype profiles of anti-influenza antibodies in mice bearing the xid defect.
作者信息
Reale M A, Bona C A, Schulman J L
出版信息
J Virol. 1985 Feb;53(2):425-9. doi: 10.1128/JVI.53.2.425-429.1985.
Abstract
The humoral response to influenza A/PR8 virus was examined in the CBA/N and C3J.xid strains of mice, both of which bear an X-linked genetic defect (xid), and in strains lacking this defect. Hemagglutination-inhibiting antibody titers and measurement of virus-specific antibodies by solid-phase radioimmunoassay indicated that the xid defect does not impair the production of an adequate anti-influenza antibody response. However, investigation of the isotypes of PR8 virus-specific antibodies disclosed a relative decrease in the levels of IgG3 and IgG1 in the xid-bearing strains. This was observed after both intraperitoneal immunization and aerosol infection. The isotype differences were not reflected in the susceptibility of these strains to influenza virus infection.
摘要
在CBA/N和C3J.xid品系小鼠（二者均携带X连锁基因缺陷（xid））以及缺乏该缺陷的品系中检测了对甲型流感病毒A/PR8的体液免疫反应。血凝抑制抗体滴度以及通过固相放射免疫测定法对病毒特异性抗体的测量表明，xid缺陷并不损害产生足够的抗流感抗体反应。然而，对PR8病毒特异性抗体的亚型研究发现，携带xid的品系中IgG3和IgG1水平相对降低。这在腹腔内免疫和气溶胶感染后均有观察到。这些品系对流感病毒感染的易感性并未体现出亚型差异。
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