病毒感染引发的小鼠抗体的IgG2a限制
IgG2a restriction of murine antibodies elicited by viral infections.
作者信息
Coutelier J P, van der Logt J T, Heessen F W, Warnier G, Van Snick J
出版信息
J Exp Med. 1987 Jan 1;165(1):64-9. doi: 10.1084/jem.165.1.64.
Abstract
The isotypic distribution of IgG antibodies was determined in the serum of mice after infection with a panel of RNA and DNA viruses representative of 11 different genera. The antiviral response induced by all these viruses showed a striking preponderance of the IgG2a subclass whatever the strain of mice tested or the time elapsed after infection. Together with the predominance of IgG1 in antiprotein and of IgG3 in anticarbohydrate response, this IgG2a restriction of antiviral antibodies strongly suggests the existence of highly specific mechanisms for the regulation of individual subclasses in the mouse.
摘要
在用一组代表11个不同属的RNA和DNA病毒感染小鼠后，测定了小鼠血清中IgG抗体的同种型分布。无论所测试的小鼠品系如何，也无论感染后经过的时间长短，所有这些病毒诱导的抗病毒反应均显示IgG2a亚类占显著优势。与抗蛋白质反应中IgG1占优势以及抗碳水化合物反应中IgG3占优势一起，抗病毒抗体的这种IgG2a限制强烈表明小鼠中存在调节各个亚类的高度特异性机制。
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