Phapale Prasad
European Molecular Biology Lab Metabolomics Core Facility Heidelberg Germany.
Anal Sci Adv. 2021 Sep 30;2(11-12):611-616. doi: 10.1002/ansa.202000178. eCollection 2021 Dec.
Pharmaco-metabolomics uses metabolic phenotypes for the prediction of inter-individual variations in drug response and helps in understanding the mechanisms of drug action. The field has made significant progress over the last 14 years with numerous studies providing clinical evidence for personalised medicine. However, discovered pharmaco-metabolomic biomarkers are not yet translated into clinics due to a lack of large-scale validation. Integration of targeted and untargeted metabolomics workflows into pharmacokinetic analysis and drug development can advance the field from bench to bedside. Also, Indian pharmaceutical research and its bioanalytical infrastructure are in a position to take on these opportunities by addressing challenges such as appropriate training and regulatory compliance.
药物代谢组学利用代谢表型来预测个体间药物反应的差异，并有助于理解药物作用机制。在过去14年里，该领域取得了重大进展，众多研究为个性化医疗提供了临床证据。然而，由于缺乏大规模验证，已发现的药物代谢组学生物标志物尚未转化应用于临床。将靶向和非靶向代谢组学工作流程整合到药代动力学分析和药物开发中，可以推动该领域从实验室走向临床应用。此外，印度的药物研究及其生物分析基础设施有能力通过应对适当培训和法规遵从性等挑战来抓住这些机遇。
