Sisco Edward, Urbas Aaron
National Institute of Standards and Technology, Gaithersburg, MD, USA.
Forensic Chem. 2023 Jul;34. doi: 10.1016/j.forc.2023.100505.
With the sustained prevalence and introduction of new emerging drugs throughout the world there is a need for continued development and maintenance of platforms that enable rapid identification and characterization of unknown compounds. To complement existing efforts, a collaborative platform between the National Institute of Standards and Technology (NIST) and practicing forensic agencies is being deployed which enables laboratories to leverage techniques and expertise that may not exist at their facilities. Using this approach, unknown compounds are identified and characterized using a suite of analytical tools to obtain (1) a rapid preliminary identification followed by (2) a more complete characterization and confirmation of the preliminary identification. To demonstrate this platform, the characterization of three previously unreported analogs of phencyclidine (PCP) - POXP, PTHP, and P2AP - are described. A preliminary identification of the three substances was obtained using direct analysis in real time mass spectrometry (DART-MS) with confirmation by nuclear magnetic resonance (NMR) spectroscopy, gas chromatography mass spectrometry (GC-MS) and gas chromatography flame ionization detection (GC-FID).
随着新型药物在全球的持续流行和不断出现，需要持续开发和维护能够快速鉴定和表征未知化合物的平台。为了补充现有工作，美国国家标准与技术研究院（NIST）与实际法医机构之间正在部署一个协作平台，该平台使实验室能够利用其设施中可能不存在的技术和专业知识。采用这种方法，使用一套分析工具对未知化合物进行鉴定和表征，以获得：（1）快速初步鉴定，随后（2）对初步鉴定进行更全面的表征和确认。为了展示这个平台，描述了苯环己哌啶（PCP）的三种以前未报告的类似物——POXP、PTHP和P2AP的表征。使用实时质谱直接分析（DART-MS）对这三种物质进行了初步鉴定，并通过核磁共振（NMR）光谱、气相色谱-质谱联用（GC-MS）和气相色谱-火焰离子化检测（GC-FID）进行了确认。
