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[白细胞介素-18及白细胞介素-18结合蛋白在骨髓增生异常综合征患者骨髓中的临床意义]

[Clinical significance of IL-18 and IL-18-binding protein in bone marrow of patients with myelodysplastic syndrome].

作者信息

Wang T, Ran N Y, Chen Q L, Liu D L, Zang M T, Li N B, He X, Guan J, Fu R, Shao Z H

机构信息

Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin 300052, China.

Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin 300052, China Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde), Changde 415003, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2024 Mar 14;45(3):284-289. doi: 10.3760/cma.j.cn121090-20231009-00178.

DOI:10.3760/cma.j.cn121090-20231009-00178
PMID:38716601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11078664/
Abstract

To analyze the level and clinical significance of IL-18 and IL-18-binding protein (BP) in the bone marrow of patients with myelodysplastic syndrome (MDS) . A total of 43 newly diagnosed patients with MDS who were admitted to the Department of Hematology, Tianjin Medical University General Hospital, from July 2020 to February 2021 were randomly selected. The control group consisted of 14 patients with acute myeloid leukemia (AML) and 25 patients with iron-deficiency anemia (IDA). The levels of IL-18 and IL-18 BP in the bone marrow supernatant were measured, and their correlations with MDS severity, as well as the functionality of CD8(+) T cells and natural killer cells, was analyzed. The levels of IL-18, IL-18 BP, and free IL-18 (fIL-18) in the bone marrow supernatant of patients with MDS were higher than in the IDA group. The level of fIL-18 was linearly and negatively correlated with the MDS-International Prognostic Scoring System (IPSS) score. IL-18 receptor (IL-18Rα) expression on CD8(+) T cells in the MDS group was lower than in the IDA group, and the levels of fIL-18 and IL-18Rα were positively correlated with CD8(+) T-cell function in the MDS group. IL-18 BP antagonizes IL-18, leading to a decrease in fIL-18 in the bone marrow microenvironment of patients with MDS, affecting CD8(+) T-cell function, which is closely related to MDS severity; therefore, it may become a new target for MDS treatment.

摘要

分析骨髓增生异常综合征（MDS）患者骨髓中白细胞介素-18（IL-18）和白细胞介素-18结合蛋白（IL-18BP）的水平及临床意义。随机选取2020年7月至2021年2月在天津医科大学总医院血液科住院的43例新诊断的MDS患者。对照组包括14例急性髓系白血病（AML）患者和25例缺铁性贫血（IDA）患者。检测骨髓上清液中IL-18和IL-18BP的水平，并分析它们与MDS严重程度以及CD8(+)T细胞和自然杀伤细胞功能的相关性。MDS患者骨髓上清液中IL-18、IL-18BP和游离IL-18（fIL-18）的水平高于IDA组。fIL-18水平与MDS国际预后评分系统（IPSS）评分呈线性负相关。MDS组CD8(+)T细胞上白细胞介素-18受体（IL-18Rα）的表达低于IDA组，MDS组中fIL-18和IL-18Rα水平与CD8(+)T细胞功能呈正相关。IL-18BP拮抗IL-18，导致MDS患者骨髓微环境中fIL-18减少，影响CD8(+)T细胞功能，这与MDS严重程度密切相关；因此，它可能成为MDS治疗的新靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/9bb3a34644b8/cjh-45-03-284-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/3b8b46ce2b6a/cjh-45-03-284-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/e4a205759b43/cjh-45-03-284-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/636110c379ea/cjh-45-03-284-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/bd7fa1f32a46/cjh-45-03-284-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/9bb3a34644b8/cjh-45-03-284-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/3b8b46ce2b6a/cjh-45-03-284-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/e4a205759b43/cjh-45-03-284-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/b9a60816fe5d/cjh-45-03-284-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/636110c379ea/cjh-45-03-284-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/bd7fa1f32a46/cjh-45-03-284-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c2/11078664/9bb3a34644b8/cjh-45-03-284-g006.jpg

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本文引用的文献

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Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review.先天性免疫/炎症途径在骨髓增生异常综合征和急性髓系白血病中的作用：一篇叙述性综述。
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