通过双导向基团策略实现的铑催化三组分C(sp)/C(sp)-H活化
Rhodium-catalyzed three-component C(sp)/C(sp)-H activation enabled by a two-fold directing group strategy.
作者信息
Hou Fu-Cheng, Zhang Jia-Le, Wang Zi-Rui, Li Zhong-Yuan
机构信息
The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China.
出版信息
Chem Commun (Camb). 2024 May 23;60(43):5634-5637. doi: 10.1039/d4cc00827h.
Rh-catalyzed three-component C(sp)/C(sp)-H activation has been achieved through a two-directing group strategy. This protocol provides a convenient and efficient pathway for the construction of diverse 8-alkyl quinoline derivatives in one-pot. Furthermore, mechanistic studies revealed that the first C-H amidation was significantly faster than the sequential C-H alkylation.
通过双导向基团策略实现了铑催化的三组分C(sp)/C(sp)-H活化。该方案为一锅法构建多种8-烷基喹啉衍生物提供了一条方便且高效的途径。此外，机理研究表明，首次C-H酰胺化明显快于后续的C-H烷基化。
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