Medical Center on Aging of Ruijin Hospital, MCARJH, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cancer Med. 2024 May;13(9):e7085. doi: 10.1002/cam4.7085.
To investigate the effect of Self-designed Metabolic Equivalent Exercises (SMEE) on cancer-related fatigue in patients with gastric cancer.
130 patients with gastric cancer admitted to Department of Oncology of a tertiary hospital in Shanghai were enrolled and assessed for eligibility. After excluding 1 patient who declined to participate, 129 eligible patients were randomly assigned into SMEE (n = 65) and control (n = 64) groups. The Revised Piper Fatigue Scale (RPFS) and EORTC QLQ-C30 Quality of Life Scale were used to measure cancer-caused fatigue and quality of life, respectively, in both groups at the first admission and after 3 months.
After excluding patients who did not receive allocated intervention due to medical (n = 3) and personal (n = 2) reasons, those who were lost to follow-up (n = 3), and those who had discontinued intervention (n = 2), 119 patients (64 in the SMEE group and 55 in the control group) were included for analysis. There were no statistically significant differences in the RPFS or QLQ-C30 score between the two groups at baseline. After 3 months, the total RPFS score of the SMEE group was significantly lower than that of the control group (2.86 ± 1.75 vs. 4.65 ± 1.29, p = 0.009), with significant improvements in affective meaning (0.83 ± 0.92 vs. 1.13 ± 0.77, p = 0.044) and sensory (0.70 ± 0.71 vs. 1.00 ± 0.54, p < 0.001) subscales; in the SMEE group, QLQ-C30 scores in somatic (2.00 ± 0.27 vs. 1.31 ± 0.26, p < 0.001), emotional (2.67 ± 0.58 vs. 2.07 ± 0.48, p < 0.001), and social (3.23 ± 0.58 vs. 1.64 ± 0.51, p < 0.001) functioning were significantly higher than those in the control group, with significant improvements in fatigue (p < 0.001), nausea/vomiting (p = 0.014), shortness of breath (p < 0.001), constipation (p < 0.001), and diarrhea (p = 0.001) dimensions.
The self-programmed metabolic equivalent manipulation as an exercise intervention could effectively reduce the degree of cancer-caused fatigue and improve quality of life in patients with gastric cancer.
探讨自设计代谢当量运动（SMEE）对胃癌患者癌因性疲劳的影响。
纳入上海某三甲医院肿瘤科的 130 例胃癌患者，并对其进行合格性评估。在排除 1 例拒绝参与的患者后，将 129 例合格患者随机分为 SMEE 组（n=65）和对照组（n=64）。采用修订版 Piper 疲劳量表（RPFS）和 EORTC QLQ-C30 生活质量量表分别于首次入院时和 3 个月后评估两组患者的癌因性疲劳和生活质量。
由于医疗（n=3）和个人（n=2）原因未接受分配干预、失访（n=3）和中断干预（n=2），排除这些患者后，共纳入 119 例患者（SMEE 组 64 例，对照组 55 例）进行分析。两组基线时 RPFS 或 QLQ-C30 评分无统计学差异。3 个月后，SMEE 组的总 RPFS 评分明显低于对照组（2.86±1.75 vs. 4.65±1.29，p=0.009），在情感意义（0.83±0.92 vs. 1.13±0.77，p=0.044）和感觉（0.70±0.71 vs. 1.00±0.54，p<0.001）亚量表上均有显著改善；在 SMEE 组中，躯体（2.00±0.27 vs. 1.31±0.26，p<0.001）、情绪（2.67±0.58 vs. 2.07±0.48，p<0.001）和社会（3.23±0.58 vs. 1.64±0.51，p<0.001）功能的 QLQ-C30 评分均明显高于对照组，疲劳（p<0.001）、恶心/呕吐（p=0.014）、呼吸困难（p<0.001）、便秘（p<0.001）和腹泻（p=0.001）维度也均有显著改善。
自设计代谢当量运动作为一种运动干预，可以有效减轻胃癌患者的癌因性疲劳程度，提高生活质量。
