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对 FOXO1 在多种癌症中的预后和免疫作用进行了广泛分析。

An extensive analysis of the prognostic and immune role of FOXO1 in various types of cancer.

机构信息

Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, West Lake University School of Medicine, Hangzhou, China.

Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, China.

出版信息

Braz J Med Biol Res. 2024 May 3;57:e13378. doi: 10.1590/1414-431X2024e13378. eCollection 2024.

DOI:10.1590/1414-431X2024e13378
PMID:38716982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11085032/
Abstract

Forkhead Box O1 (FOXO1) has been reported to play important roles in many tumors. However, FOXO1 has not been studied in pan-cancer. The purpose of this study was to reveal the roles of FOXO1 in pan-cancer (33 cancers in this study). Through multiple public platforms, a pan-cancer analysis of FOXO1 was conducted to obtained FOXO1 expression profiles in various tumors to explore the relationship between FOXO1 expression and prognosis of these tumors and to disclose the potential mechanism of FOXO1 in these tumors. FOXO1 was associated with the prognosis of multiple tumors, especially LGG (low grade glioma), OV (ovarian carcinoma), and KIRC (kidney renal clear cell carcinoma). FOXO1 might play the role of an oncogenic gene in LGG and OV, while playing the role of a cancer suppressor gene in KIRC. FOXO1 expression had a significant correlation with the infiltration of some immune cells in LGG, OV, and KIRC. By combining FOXO1 expression and immune cell infiltration, we found that FOXO1 might influence the overall survival of LGG through the infiltration of myeloid dendritic cells or CD4+ T cells. Functional enrichment analysis and gene set enrichment analysis showed that FOXO1 might play roles in tumors through immunoregulatory interactions between a lymphoid and a non-lymphoid cell, TGF-beta signaling pathway, and transcriptional misregulation in cancer. FOXO1 was associated with the prognosis of multiple tumors, especially LGG, OV, and KIRC. In these tumors, FOXO1 might play its role via the regulation of the immune microenvironment.

摘要

叉头框蛋白 O1（FOXO1）已被报道在许多肿瘤中发挥重要作用。然而，FOXO1 在泛癌症中尚未得到研究。本研究的目的是揭示 FOXO1 在泛癌症（本研究中的 33 种癌症）中的作用。通过多个公共平台，对 FOXO1 进行了泛癌症分析，以获得各种肿瘤中 FOXO1 的表达谱，探讨 FOXO1 表达与这些肿瘤预后的关系，并揭示 FOXO1 在这些肿瘤中的潜在机制。FOXO1 与多种肿瘤的预后相关，尤其是 LGG（低级别胶质瘤）、OV（卵巢癌）和 KIRC（肾透明细胞癌）。FOXO1 可能在 LGG 和 OV 中发挥癌基因的作用，而在 KIRC 中发挥抑癌基因的作用。FOXO1 表达与 LGG、OV 和 KIRC 中一些免疫细胞的浸润有显著相关性。通过结合 FOXO1 表达和免疫细胞浸润，我们发现 FOXO1 可能通过髓样树突状细胞或 CD4+T 细胞的浸润影响 LGG 的总生存率。功能富集分析和基因集富集分析表明，FOXO1 可能通过淋巴样和非淋巴样细胞之间的免疫调节相互作用、TGF-β信号通路和癌症转录失调在肿瘤中发挥作用。FOXO1 与多种肿瘤的预后相关，尤其是 LGG、OV 和 KIRC。在这些肿瘤中，FOXO1 可能通过调节免疫微环境发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/4d2842d5043a/1414-431X-bjmbr-57-e13378-gf010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/024bc26a02a1/1414-431X-bjmbr-57-e13378-gf001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/38eb336ac599/1414-431X-bjmbr-57-e13378-gf002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/9a4de7bed32d/1414-431X-bjmbr-57-e13378-gf003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/54a09f01fbb4/1414-431X-bjmbr-57-e13378-gf004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/99df38161c1d/1414-431X-bjmbr-57-e13378-gf005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/10391b87db5f/1414-431X-bjmbr-57-e13378-gf006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/cf11a62f25ed/1414-431X-bjmbr-57-e13378-gf007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/3f0297ebd626/1414-431X-bjmbr-57-e13378-gf008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/fa8d96cc9e3f/1414-431X-bjmbr-57-e13378-gf009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/4d2842d5043a/1414-431X-bjmbr-57-e13378-gf010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/024bc26a02a1/1414-431X-bjmbr-57-e13378-gf001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/38eb336ac599/1414-431X-bjmbr-57-e13378-gf002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/9a4de7bed32d/1414-431X-bjmbr-57-e13378-gf003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/54a09f01fbb4/1414-431X-bjmbr-57-e13378-gf004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/99df38161c1d/1414-431X-bjmbr-57-e13378-gf005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/10391b87db5f/1414-431X-bjmbr-57-e13378-gf006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/cf11a62f25ed/1414-431X-bjmbr-57-e13378-gf007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/3f0297ebd626/1414-431X-bjmbr-57-e13378-gf008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/fa8d96cc9e3f/1414-431X-bjmbr-57-e13378-gf009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/11085032/4d2842d5043a/1414-431X-bjmbr-57-e13378-gf010.jpg

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