Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China.
Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, 116000, China.
Adv Healthc Mater. 2024 Sep;13(23):e2400927. doi: 10.1002/adhm.202400927. Epub 2024 Jun 4.
In recent years, the demand for clinical bone grafting has increased. As a new solution for orthopedic implants, polyether ether ketone (PEEK, crystalline PAEK) has excellent comprehensive performance and is practically applied in the clinic. In this research, a noteworthy elevated scheme to enhance the performance of PEEK scaffolds is presented. The amorphous aggregated poly (aryl ether ketone) (PAEK) resin is prepared as the matrix material, which maintains high mechanical strength and can be processed through the solution. So, the tissue engineering scaffolds with multilevel pores can be printed by low-temperature deposited manufacturing (LDM) to improve biologically inert scaffolds with smooth surfaces. Also, the feature of PAEK's solution processing is profitable to uniformly add the functional components for bone repair. Ultimately, A system of orthopedic implantable PAEK material based on intermolecular interactions, surface topology, and surface modification is established. The specific steps include synthesizing PAEK that contain polar carboxyl structures, preparing bioinks and fabricating scaffolds by LDM, preparation of scaffolds with strontium-doped mineralized coatings, evaluation of their osteogenic properties in vitro and in vivo, and investigation on the effect and mechanism of scaffolds in promoting osteogenic differentiation. This work provides an upgraded system of PAEK implantable materials for clinical application.
近年来，临床骨移植的需求不断增加。聚醚醚酮（PEEK，结晶型聚芳醚酮）作为骨科植入物的一种新解决方案，具有优异的综合性能，已在临床上得到实际应用。本研究提出了一种提高 PEEK 支架性能的显著改进方案。采用非晶态聚集的聚芳醚酮（PAEK）树脂作为基体材料，保持了较高的机械强度，可通过溶液进行加工。因此，可以通过低温沉积制造（LDM）打印出具有多级孔的组织工程支架，以改善具有光滑表面的生物惰性支架。此外，PAEK 溶液加工的特点有利于均匀添加用于骨修复的功能成分。最终，建立了基于分子间相互作用、表面拓扑和表面改性的骨科植入用 PAEK 材料体系。具体步骤包括合成含有极性羧基结构的 PAEK，制备生物墨水并通过 LDM 制造支架，制备掺锶矿化涂层的支架，评估其体外和体内成骨性能，并研究支架在促进成骨分化方面的作用和机制。本工作为临床应用提供了一种升级的 PAEK 植入材料系统。
