State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
University of Science and Technology of China, Hefei, 230026, P. R. China.
Adv Healthc Mater. 2022 Sep;11(18):e2200977. doi: 10.1002/adhm.202200977. Epub 2022 Jul 19.
Polyetheretherketone (PEEK) as a popular orthopaedic implant is usually fabricated into a hierarchically porous structure for improving osteogenic activity. However, the applications are limited due to the excessively high processing temperature and uncontrollably tedious modification routes. Here, an amorphous polyaryletherketone with carboxyl groups (PAEK-COOH) is synthesized and fabricated to the hierarchically controllable porous scaffolds via a low-temperature 3D-printing process. The prepared PAEK-COOH scaffolds present controllable porous structures ranging from nano- to micro-scale, and their mechanical strengths are comparable to that of trabecular bone. More importantly, the in vitro experiments show that the nanoporous surface is conducive to promoting cellular adhesion, and carboxyl groups can induce hydroxyapatite mineralization via electrostatic interaction. The in vivo experiments demonstrate that the PAEK-COOH scaffolds offer much better osseointegration without additional active ingredients, compared to that of PEEK. Therefore, this work will not only develop a promising candidate for bone tissue engineering, but provide a viable method to design PAEK biomaterials.
聚醚醚酮（PEEK）作为一种流行的骨科植入物，通常被制成具有层次多孔结构，以提高成骨活性。然而，由于过高的加工温度和难以控制的繁琐改性途径，其应用受到限制。在这里，合成了一种具有羧基的无定形聚芳醚酮（PAEK-COOH），并通过低温 3D 打印工艺制备成层次可控的多孔支架。所制备的 PAEK-COOH 支架呈现出从纳米到微米尺度的可控多孔结构，其机械强度与小梁骨相当。更重要的是，体外实验表明，纳米多孔表面有利于促进细胞黏附，而羧基基团可以通过静电相互作用诱导羟基磷灰石矿化。体内实验表明，与 PEEK 相比，PAEK-COOH 支架在没有额外活性成分的情况下提供了更好的骨整合。因此，这项工作不仅为骨组织工程开发了一种很有前途的候选材料，而且为设计 PAEK 生物材料提供了一种可行的方法。
