Department of Neurological Surgery, University of Pittsburgh, 4401 Penn Ave, Fl 4, Pittsburgh, PA, USA.
Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA.
Childs Nerv Syst. 2024 Aug;40(8):2491-2495. doi: 10.1007/s00381-024-06397-6. Epub 2024 May 8.
To assess preferences and outcome expectations for vagus nerve stimulation (VNS) and corpus callosotomy (CC) surgeries in the treatment of atonic seizure in Lennox-Gastaut syndrome (LGS).
A total of 260 surveys were collected from patients are caregivers of LGS patients via Research Electronic Data Capture (REDCap).
Respondents reported an average acceptable atonic seizure reduction rate of 55.9% following VNS and 74.7% following CC. 21.3% (n = 50) were willing to be randomized. Respondents reported low willingness for randomization and a higher seizure reduction expectation with CC.
Our findings guide surgical approaches for clinicians to consider patient preference in order to design future studies comparing effectiveness between these two procedures.
评估迷走神经刺激（VNS）和胼胝体切开术（CC）治疗 Lennox-Gastaut 综合征（LGS）患者强直发作的偏好和结果预期。
通过 Research Electronic Data Capture（REDCap）共从 LGS 患者及其照顾者中收集了 260 份调查。
受访者报告 VNS 治疗后平均可接受的强直发作减少率为 55.9%，CC 治疗后为 74.7%。21.3%（n=50）愿意随机化。受访者报告说，他们对随机化的意愿较低，而对 CC 的癫痫发作减少预期较高。
我们的研究结果为临床医生提供了手术方法指导，以考虑患者的偏好，从而为比较这两种手术效果的未来研究设计提供依据。
