Institute of Social Medicine and Global Challenges, School of Health Sciences, School of Medicine, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Université Paris Cité, Inserm, IAME, Paris, France.
PLoS One. 2024 May 8;19(5):e0285648. doi: 10.1371/journal.pone.0285648. eCollection 2024.
Acne is a common disease that is associated with scarring and substantial psychosocial burden. The Global Burden of Skin Disease reported that the burden from acne as measured by disability-adjusted life years (DALYs) from 188 countries and specifically that it is greatest in Western Europe, high-income North America and Southern Latin America. This paper aimed to identify risk factors for acne scarring specific to the Ecuadorian population in order to adapt the 4-ASRAT tool accordingly.
This was an observational prospective study. Participants were recruited to complete a survey that was developed based on the potential risk factors for acne scarring and had facial photographs taken. To determine risk factors and their respective weighting, a logistic regression was performed.
The study included 404 participants. Results from univariate analyses indicated that being male (OR = 2.76 95%CI [1.72; 4.43]), having severe or very severe acne scarring (OR = 4.28 95%CI [1.24; 14.79]), acne duration over 1 year (OR = 1.71 95%CI [1.12; 2.60]), oily skin (OR = 2.02 95%CI [1.27; 3.22]) and the presence of acne on the neck (OR = 2.26 95%CI [1.30; 3.92]), were all significantly associated with the presence of acne scarring. Male sex (2.56 95%CI [1.58;4.17]), oily skin (1.96 95%CI [1.20;3.20]) and severe or very severe acne (3.75 95%CI [1.05;13.37]) remained significant risk factors for acne scarring in the multivariate analysis.
By identifying acne scarring risk factors and applying the tool in everyday dermatology visits, we can reduce the physical and psychological burden that acne scarring causes in the adolescent and adult populations. Further research should be conducted to reassess potential risk factors and complete the adaptation of the tool for the Ecuadorian population, with a larger and more representative study population.
痤疮是一种常见的疾病，与疤痕和严重的心理社会负担有关。《全球皮肤病负担》报告称，从残疾调整生命年（DALYs）的角度衡量，来自 188 个国家的痤疮负担最大，特别是在西欧、高收入北美和南拉丁美洲。本文旨在确定厄瓜多尔人群中痤疮疤痕的特定危险因素，以便相应地调整 4-ASRAT 工具。
这是一项观察性前瞻性研究。招募参与者完成一项基于痤疮疤痕潜在危险因素的调查，并拍摄面部照片。为了确定危险因素及其各自的权重，进行了逻辑回归分析。
该研究纳入了 404 名参与者。单因素分析结果表明，男性（OR=2.76，95%CI[1.72;4.43]）、有严重或非常严重的痤疮疤痕（OR=4.28，95%CI[1.24;14.79]）、痤疮持续时间超过 1 年（OR=1.71，95%CI[1.12;2.60]）、油性皮肤（OR=2.02，95%CI[1.27;3.22]）和颈部有痤疮（OR=2.26，95%CI[1.30;3.92]）与痤疮疤痕的存在均显著相关。男性（2.56，95%CI[1.58;4.17]）、油性皮肤（1.96，95%CI[1.20;3.20]）和严重或非常严重的痤疮（3.75，95%CI[1.05;13.37]）在多变量分析中仍然是痤疮疤痕的显著危险因素。
通过识别痤疮疤痕的危险因素，并在日常皮肤科就诊中应用该工具，我们可以减轻痤疮疤痕给青少年和成年人群带来的身体和心理负担。应进一步开展研究，重新评估潜在的危险因素，并完成针对厄瓜多尔人群的工具调整，采用更大、更具代表性的研究人群。
