从一名健康男性供者中生成一个控制诱导多能干细胞系（SDUCHi001-A）。
Generation of a control induced pluripotent stem cell line (SDUCHi001-A) from a healthy male donor.
机构信息
Department of Blood Transfusion, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China.
Weifang Municipal Center for Disease Control and Prevention, Weifang, Shandong 261061, China.
出版信息
Stem Cell Res. 2024 Jun;77:103433. doi: 10.1016/j.scr.2024.103433. Epub 2024 Apr 30.
An induced pluripotent stem cell (iPSC) line (SDUCHi001-A) was established using peripheral blood mononuclear cells (PBMCs) from a healthy 6 years old boy. Reprogramming of the PBMCs was achieved through non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL, and c-MYC. The iPSC line expressed pluripotency markers, had a normal karyotype and trilineage differentiation potential.
诱导多能干细胞（iPSC）系（SDUCHi001-A）是通过取自健康 6 岁男孩外周血单个核细胞（PBMC）建立的。通过非整合型载体 OCT4、SOX2、KFL4、BCL-XL 和 c-MYC 对 PBMC 进行重编程。该 iPSC 系表达多能性标志物，具有正常核型和三系分化潜能。
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