Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China
BMJ Open. 2024 May 7;14(5):e075783. doi: 10.1136/bmjopen-2023-075783.
Exercise has been used to reverse dysglycaemic states in patients with pre-diabetes. Systematic reviews show that exercise is an effective way to reduce the incidence of diabetes, but there is conflicting evidence for reducing the occurrence of cardiovascular events. Therefore, we present a systematic review and network meta-analysis protocol designed to compare the effectiveness of different forms of exercise in reducing cardiovascular events and their tolerability in different populations.
We will include all randomised controlled trials and compare one exercise intervention to another. We will compare the following exercise patterns: standard endurance training, strength training, high-intensity interval training, mind-body exercise, and mixed strength and aerobic training. The primary outcomes are the occurrence of major cardiovascular events and the rate of patient attrition during the intervention. We will search major English and Chinese databases as well as trial registry websites for published and unpublished studies. All reference selection and data extraction will be conducted by at least two independent reviewers. We will conduct a random effects model to combine effect sizes and use the surface under the cumulative ranking curve and the mean ranks to rank the effectiveness of interventions. All data will be fitted at WinBUGS in a Bayesian framework and correlation graphs will be plotted using StataSE 14. We will also use the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework to evaluate the quality of evidence for the study results.
This study does not involve a population-based intervention, and therefore, does not require ethical approval. We will publish the findings of this systematic review in a peer-reviewed scientific journal, and the dataset will be made available free of charge. The completed review will be disseminated electronically in print and on social media, where appropriate.
CRD42023422737.
运动已被用于逆转糖尿病前期患者的糖代谢异常状态。系统评价显示，运动是降低糖尿病发病率的有效方法，但在降低心血管事件发生率方面的证据存在冲突。因此，我们提出了一项系统评价和网络荟萃分析方案，旨在比较不同形式的运动在降低不同人群心血管事件发生率及其耐受性方面的效果。
我们将纳入所有随机对照试验，并比较一种运动干预与另一种运动干预。我们将比较以下运动模式：标准耐力训练、力量训练、高强度间歇训练、身心运动和混合力量与有氧训练。主要结局是主要心血管事件的发生和干预期间患者的失访率。我们将在主要的英文和中文数据库以及试验注册网站上搜索已发表和未发表的研究。所有参考文献的选择和数据提取将由至少两名独立评审员进行。我们将采用随机效应模型来合并效应大小，并使用累积排序曲线下面积和平均秩来对干预效果进行排名。所有数据将在 WinBUGS 中以贝叶斯框架拟合，并使用 StataSE 14 绘制相关图。我们还将使用推荐评估、制定与评估（GRADE）框架来评估研究结果证据的质量。
本研究不涉及基于人群的干预，因此不需要伦理批准。我们将在同行评议的科学期刊上发表这项系统评价的结果，并免费提供数据集。完成的综述将以电子方式在印刷品和社交媒体上传播，视情况而定。
PROSPERO 注册号：CRD42023422737。
