Grodin Erica N, Burnette Elizabeth M, Rodriguez Crystal, Fulcher Jennifer A, Ray Lara A
Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Alcohol Clin Exp Res (Hoboken). 2024 Jul;48(7):1221-1242. doi: 10.1111/acer.15338. Epub 2024 May 8.
Evidence suggests that a relationship exists between the gut microbiome and the pathogenesis of alcohol use disorder (AUD) and alcohol-associated liver disease (AALD). This systematic review identified studies that investigated the gut microbiome in individuals with an AUD or an AALD. A search was conducted on October 27, 2022, in PubMed, Web of Science, and Embase databases. Fifty studies satisfied eligibility criteria. Most studies found evidence for gut dysbiosis in individuals with AUD and AALD. Microbiome intervention studies have mostly been conducted in AALD patients; fecal microbial transplant interventions show the most promise. Because most studies were conducted cross-sectionally, the causal relationship between the gut microbiome and alcohol use is unknown. Furthermore, almost all studies have been conducted in predominantly male populations, leaving critical questions regarding sex differences and generalizability of the findings. The study summaries and recommendations provided in this review seek to identify areas for further research and to highlight potential gut microbial interventions for treating AUD and AALD.
有证据表明，肠道微生物群与酒精使用障碍（AUD）及酒精相关肝病（AALD）的发病机制之间存在关联。本系统评价纳入了针对AUD或AALD患者肠道微生物群的研究。于2022年10月27日在PubMed、科学网和Embase数据库进行了检索。50项研究符合纳入标准。大多数研究发现了AUD和AALD患者肠道菌群失调的证据。微生物群干预研究大多在AALD患者中进行；粪便微生物移植干预显示出最大的前景。由于大多数研究为横断面研究，肠道微生物群与酒精使用之间的因果关系尚不清楚。此外，几乎所有研究均在以男性为主的人群中进行，这使得关于性别差异及研究结果普遍性的关键问题悬而未决。本综述提供的研究总结和建议旨在确定进一步研究的领域，并强调治疗AUD和AALD的潜在肠道微生物干预措施。
