Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
BMC Gastroenterol. 2024 May 8;24(1):156. doi: 10.1186/s12876-024-03215-w.
Mucoepidermoid Carcinoma of the Esophagus (MECE) is a relatively rare tumor type, with most of the current data derived from case reports or small sample studies. This retrospective study reports on the 10-year survival data and detailed clinicopathological characteristics of 48 patients with esophageal MEC.
Data were collected from 48 patients who underwent curative surgery for esophageal MEC at the Fourth Hospital of Hebei Medical University between January 1, 2004, and December 31, 2020. These were compared with contemporaneous cases of Esophageal Squamous Cell Carcinoma (ESCC) and Esophageal Adenocarcinoma (EAC). Using the Kaplan-Meier method and multivariate Cox regression analysis, we investigated the clinicopathological factors affecting the survival of patients with MEC.
The incidence of MECE was predominantly higher in males, with a male-to-female ratio of approximately 7:1. The mid-thoracic segment emerged as the most common site of occurrence. A mere 6.3% of cases were correctly diagnosed preoperatively. The lymph node metastasis rate stood at 35.4%. The overall 1-year, 3-year, 5-year, and 10-year survival rates for all patients were 85.4%, 52.1%, 37.0%, and 31.0%, respectively. Post 1:1 propensity score matching, no significant statistical difference was observed in the Overall Survival (OS) between MEC patients and those with Esophageal Squamous Cell Carcinoma (ESCC) and Esophageal Adenocarcinoma (EAC) (P = 0.119, P = 0.669). Univariate analysis indicated that T staging and N staging were the primary factors influencing the prognosis of esophageal MEC.
MECE occurs more frequently in males than females, with the mid-thoracic segment being the most common site of occurrence. The rate of accurate preoperative endoscopic diagnosis is low. The characteristic of having a short lesion length yet exhibiting significant extramural invasion may be a crucial clinicopathological feature of MECE. The OS of patients with MEC does not appear to significantly differ from those with esophageal squamous carcinoma and adenocarcinoma.
食管黏液表皮样癌（MECE）是一种相对罕见的肿瘤类型，目前大多数数据来自病例报告或小样本研究。本回顾性研究报告了 48 例食管 MEC 患者的 10 年生存数据和详细的临床病理特征。
收集 2004 年 1 月 1 日至 2020 年 12 月 31 日期间在河北医科大学第四医院接受根治性手术治疗的 48 例食管 MEC 患者的数据，并与同期食管鳞癌（ESCC）和食管腺癌（EAC）患者进行比较。采用 Kaplan-Meier 法和多因素 Cox 回归分析，探讨影响 MEC 患者生存的临床病理因素。
MECE 的发病率男性明显高于女性，男女比例约为 7:1。最常见的发病部位是中胸段。仅有 6.3%的病例术前诊断正确。淋巴结转移率为 35.4%。所有患者的 1 年、3 年、5 年和 10 年总生存率分别为 85.4%、52.1%、37.0%和 31.0%。1:1 倾向评分匹配后，MEC 患者与 ESCC 和 EAC 患者的总生存率（OS）无统计学差异（P=0.119，P=0.669）。单因素分析表明，T 分期和 N 分期是影响食管 MEC 预后的主要因素。
MECE 男性多于女性，中胸段最常见。术前内镜诊断准确率低。病变长度短但有明显外侵的特点可能是 MECE 的重要临床病理特征。MEC 患者的 OS 似乎与食管鳞癌和腺癌患者无显著差异。
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