Sopić Miron, Vladimirov Sandra, Munjas Jelena, Mitić Tijana, Hall Ignacio Fernando, Jusic Amela, Ruzic Dusan, Devaux Yvan
Cardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Br J Pharmacol. 2025 Jan;182(2):220-245. doi: 10.1111/bph.16412. Epub 2024 May 8.
Noncoding RNAs (ncRNAs) are pivotal for various pathological processes, impacting disease progression. The potential for leveraging ncRNAs to prevent or treat atherosclerosis and associated cardiovascular diseases is of great significance, especially given the increasing prevalence of atherosclerosis in an ageing and sedentary population. Together, these diseases impose a substantial socio-economic burden, demanding innovative therapeutic solutions. This review explores the potential of ncRNAs in atherosclerosis treatment. We commence by examining approaches for identifying and characterizing atherosclerosis-associated ncRNAs. We then delve into the functional aspects of ncRNAs in atherosclerosis development and progression. Additionally, we review current RNA and RNA-targeting molecules in development or under approval for clinical use, offering insights into their pharmacological potential. The importance of improved ncRNA delivery strategies is highlighted. Finally, we suggest avenues for advanced research to accelerate the use of ncRNAs in treating atherosclerosis and mitigating its societal impact. LINKED ARTICLES: This article is part of a themed issue Non-coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc.
非编码RNA（ncRNAs）在各种病理过程中起着关键作用，影响疾病进展。鉴于在老龄化和久坐不动的人群中动脉粥样硬化的患病率不断上升，利用ncRNAs预防或治疗动脉粥样硬化及相关心血管疾病的潜力具有重要意义。这些疾病共同构成了巨大的社会经济负担，需要创新的治疗解决方案。本综述探讨了ncRNAs在动脉粥样硬化治疗中的潜力。我们首先研究识别和表征与动脉粥样硬化相关的ncRNAs的方法。然后深入探讨ncRNAs在动脉粥样硬化发展和进展中的功能方面。此外，我们回顾了目前正在开发或已获批准用于临床的RNA和靶向RNA的分子，深入了解它们的药理学潜力。强调了改进ncRNA递送策略的重要性。最后，我们提出了进一步研究的途径，以加速ncRNAs在治疗动脉粥样硬化和减轻其社会影响方面的应用。相关文章：本文是主题为“非编码RNA治疗学”的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc。
