Brook I
Am J Dis Child. 1985 Mar;139(3):280-3.
Aspiration of the exudate through open perforation was performed in 48 children with chronic suppurative otitis media. Eighty-two aerobic and 93 anaerobic isolates were recovered. Aerobic bacteria only were involved in 22 patients (46%), and anaerobic organisms only were involved in five patients (10%). Mixed aerobic and anaerobic isolates were recovered from 21 patients (44%). The most common bacteria isolated were Bacteroides melaninogenicus group (40% of patients), Pseudomonas aeruginosa (29%), Klebsiella pneumoniae (10%), and Staphylococcus aureus (10%). There were 50 beta-lactamase-producing organisms (26 anaerobes and 24 aerobes) recovered from 33 patients (69%). Forty-four of these bacteria were isolated from the 37 patients recently treated with a penicillin. These included all ten isolates of S aureus and Bacteroides fragilis group, 11 of 19 of B melaninogenicus group, five of the 14 P aeruginosa, three of ten K pneumoniae, three of six of Bacteroides oralis, four of six of Haemophilus influenzae, two of three of Staphylococcus epidermidis, and two of four of Branhamella catarrhalis. The beta-lactamase-producing organisms have a possible role in the failure of penicillin therapy.
对48例慢性化脓性中耳炎患儿进行了经开放穿孔的渗出液抽吸。共分离出82株需氧菌和93株厌氧菌。仅需氧菌感染的有22例（46%），仅厌氧菌感染的有5例（10%）。21例（44%）分离出需氧菌和厌氧菌混合感染。最常见的分离菌为产黑色素类杆菌属（占患者的40%）、铜绿假单胞菌（29%）、肺炎克雷伯菌（10%）和金黄色葡萄球菌（10%）。从33例患者（69%）中分离出50株产β-内酰胺酶的微生物（26株厌氧菌和24株需氧菌）。其中44株细菌是从37例近期接受青霉素治疗的患者中分离出来的。这些细菌包括所有10株金黄色葡萄球菌和脆弱类杆菌属分离株、产黑色素类杆菌属19株中的11株、铜绿假单胞菌14株中的5株、肺炎克雷伯菌10株中的3株、口腔类杆菌6株中的3株、流感嗜血杆菌6株中的4株、表皮葡萄球菌3株中的2株以及卡他布兰汉菌4株中的2株。产β-内酰胺酶的微生物可能是青霉素治疗失败的原因之一。
