Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Unity Health, Toronto, Ontario, Canada.
HIV Med. 2024 Sep;25(9):1007-1018. doi: 10.1111/hiv.13654. Epub 2024 May 9.
The COVID-19 pandemic has changed healthcare service delivery. We examined the overall impact of COVID-19 on people living with HIV in British Columbia (BC), Canada, with a special focus on the potential impact of COVID-19 on antiretroviral treatment interruptions (TIs).
Purposive sampling was used to enrol people living with HIV aged ≥19 years across BC into the STOP HIV/AIDS Program Evaluation study between January 2016 and September 2018. Participants completed surveys at baseline enrolment and 18 and 36 months later. Additional COVID-19 questions were added to the survey in October 2020. TIs were defined as >60 days late for antiretroviral therapy (ART) refill using data from the BC HIV Drug Treatment Program. Generalized linear mixed models were used to examine trends in TIs over time and associations with reported health service access.
Of 581 participants, 6.1%-7.7% experienced a TI during each 6-month period between March 2019 and August 2021. The frequency of TIs did not statistically increase during the COVID-19 epidemic. Among the 188 participants who completed the COVID-19 questionnaire, 32.8% reported difficulty accessing healthcare during COVID-19, 9.7% reported avoiding continuing a healthcare service due to COVID-19-related concerns, and 74.6% reported using virtual healthcare services since March 2020. In multivariable analysis, the odds of a TI in any 6-month period were not significantly different from March to August 2019. None of the reported challenges to healthcare services were associated with TIs.
Although some participants reported challenges to accessing services or avoidance of services due to COVID-19, TIs were not more likely during COVID-19 than before.
COVID-19 大流行改变了医疗保健服务的提供方式。我们研究了 COVID-19 对加拿大不列颠哥伦比亚省(BC)艾滋病毒感染者的整体影响,特别关注 COVID-19 对抗逆转录病毒治疗中断(TI)的潜在影响。
采用目的性抽样方法,于 2016 年 1 月至 2018 年 9 月期间在不列颠哥伦比亚省招募了年龄≥19 岁的艾滋病毒感染者参加 STOP HIV/AIDS 项目评估研究。参与者在基线入组时以及 18 个月和 36 个月后完成了调查。2020 年 10 月,调查中增加了关于 COVID-19 的问题。抗逆转录病毒治疗(ART)药物的续药时间超过 60 天被定义为 TI,数据来源于不列颠哥伦比亚省 HIV 药物治疗项目。使用广义线性混合模型来研究 TI 随时间的变化趋势及其与报告的卫生服务获取之间的关联。
在 581 名参与者中,在 2019 年 3 月至 2021 年 8 月的每个 6 个月期间,有 6.1%-7.7%的参与者发生了 TI。在 COVID-19 流行期间,TI 的频率并没有统计学上的增加。在完成 COVID-19 问卷调查的 188 名参与者中,有 32.8%的人报告在 COVID-19 期间难以获得医疗保健服务,9.7%的人报告因 COVID-19 相关顾虑而避免继续某项医疗保健服务,74.6%的人报告自 2020 年 3 月以来使用了虚拟医疗保健服务。在多变量分析中,任何 6 个月期间发生 TI 的可能性与 2019 年 3 月至 8 月相比没有显著差异。报告的医疗服务挑战与 TI 无关。
尽管一些参与者报告在 COVID-19 期间面临获取服务或避免服务的挑战,但与 COVID-19 之前相比,TI 并没有更有可能发生。