Liang Ping, Zhang Jie, Hou Juan, Feng Rui, Yin Jintuo
Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, China.
Tianjin University, Nankai District, 300072, Tianjin, China.
Heliyon. 2024 Apr 26;10(9):e29906. doi: 10.1016/j.heliyon.2024.e29906. eCollection 2024 May 15.
Ginsenoside Rg1 (Rg1), a monomer saponin component, is one of the components with the highest content in total saponins of Panaxnotoginseng. It had various pharmacological effects. The bioavailability of oral tablets is only 1-20 %, and it is eliminated quickly in the blood. The development of new dosage forms and new routes of administration of ginsenoside Rg1 with sustained release and high bioavailability has become a significant problem to be solved. The Rg1 liposomes study used a thin film dispersion ultrasound method for its preparation. This study focused the pharmacokinetic parameters of ginsenoside Rg1 liposomes in rats through the lung perfusion method. Ginsenoside Rg1 liposomes were round and uniform in shape, the particle size was 2-3 μm, and the encapsulation efficiency of ginsenoside Rg1 liposome was 51.2 %. Results showed that, after pulmonary administration of ginsenoside Rg1, the time of ginsenoside Rg1 detected by Rg1 liposomes was longer than that of Rg1 solution, the relative bioavailability of ginsenoside Rg1 liposome lung administration AUC /AUC = 122.67 %. These results provided the scientific theoretical and experimental basis for further development of new dosage forms and new routes of administration of ginsenoside Rg1.
人参皂苷Rg1（Rg1）是一种单体皂苷成分，是三七总皂苷中含量最高的成分之一。它具有多种药理作用。口服片剂的生物利用度仅为1%-20%，且在血液中消除迅速。开发具有缓释和高生物利用度的人参皂苷Rg1新剂型和新给药途径已成为亟待解决的重要问题。Rg1脂质体的研究采用薄膜分散超声法制备。本研究通过肺灌注法重点研究了人参皂苷Rg1脂质体在大鼠体内的药代动力学参数。人参皂苷Rg1脂质体形状圆整、均匀，粒径为2-3μm，人参皂苷Rg1脂质体的包封率为51.2%。结果表明，人参皂苷Rg1经肺部给药后，Rg1脂质体检测到人参皂苷Rg1的时间长于Rg1溶液，人参皂苷Rg1脂质体肺部给药的相对生物利用度AUC/AUC = 122.67%。这些结果为进一步开发人参皂苷Rg1的新剂型和新给药途径提供了科学的理论和实验依据。
