Gresty M A, Barratt H J, Page N G, Ell J J
Ann Neurol. 1985 Feb;17(2):129-36. doi: 10.1002/ana.410170205.
The vestibulo-ocular reflex and its suppression by fixation of a target rotating with the subject were tested in 18 subjects with congenital nystagmus using steps of constant velocity rotation and sinusoidal stimuli swept in frequency between 0.01 and 1.0 Hz. Responses to stopping stimuli were abnormal in waveform and of short duration in most subjects tested. This pattern was attributed to masking of the response by spontaneous eye movements and to adaptation. In contrast, during both oscillation in the dark and attempted suppression of the vestibulo-ocular reflex, all subjects had nystagmus that was modulated with the stimulus during all frequencies of stimulation. The phase relationship of the nystagmus to the motion stimulus was the same as in normal subjects. Estimates of the gain of the vestibulo-ocular reflex response were not meaningful because of contamination of the vestibular response by the congenital nystagmus waveforms. Modulation of amplitude and reversal of nystagmus in phase with the vestibular stimulus at all frequencies of oscillation were shown most clearly during attempted suppression of the vestibulo-ocular reflex. This finding is clinically useful because it establishes suppression as a test of the presence of vestibular function in congenital nystagmus.
对18名先天性眼球震颤患者进行了前庭眼反射及其对随受试者旋转的目标进行注视时的抑制作用测试，采用等速旋转步骤和频率在0.01至1.0Hz之间扫描的正弦刺激。在大多数受试对象中，对停止刺激的反应波形异常且持续时间短。这种模式归因于自发眼动对反应的掩盖以及适应性。相比之下，在黑暗中振荡以及试图抑制前庭眼反射期间，所有受试者在所有刺激频率下都有随刺激调制的眼球震颤。眼球震颤与运动刺激的相位关系与正常受试者相同。由于先天性眼球震颤波形对前庭反应的污染，前庭眼反射反应增益的估计没有意义。在试图抑制前庭眼反射期间，最清楚地显示了在所有振荡频率下眼球震颤幅度的调制以及与前庭刺激相位相反的眼球震颤反转。这一发现具有临床实用性，因为它将抑制确立为先天性眼球震颤中前庭功能存在与否的一项测试。
