Lazzarino M, Morra E, Rosso R, Brusamolino E, Pagnucco G, Castello A, Ghisolfi A, Tafi A, Zennaro G, Bernasconi C
Cancer. 1985 May 1;55(9):1907-12. doi: 10.1002/1097-0142(19850501)55:9<1907::aid-cncr2820550913>3.0.co;2-j.
Of 325 consecutive cases of non-Hodgkin's malignant lymphomas, 8 patients (2.4%) showed orbital presentation. The clinicopathologic and immunologic analysis of the eight patients revealed characteristic biologic features. Despite the apparently isolated orbital presentation, all cases had subclinical systemic disease. Seven of the eight cases exhibited lymphoplasmacytic/cytoid features, with concurrent type II cryoglobulinemia in five of them. In addition, during their clinical course, five patients showed single or multiple subcutaneous nodules with the same histologic and immunologic pattern as the orbital tumor. This study demonstrates that most orbital lymphomas share particular clinicopathologic and immunologic features, suggesting an origin from a B-cell subset with preferential homing to orbital tissues and subcutis.
在325例连续性非霍奇金恶性淋巴瘤病例中，8例（2.4%）表现为眼眶受累。对这8例患者进行的临床病理和免疫分析揭示了其特征性生物学特性。尽管表面上仅表现为眼眶受累，但所有病例均有亚临床系统性疾病。8例中的7例表现为淋巴浆细胞样/细胞样特征，其中5例同时伴有II型冷球蛋白血症。此外，在其临床病程中，5例患者出现单个或多个皮下结节，其组织学和免疫模式与眼眶肿瘤相同。本研究表明，大多数眼眶淋巴瘤具有特定的临床病理和免疫特征，提示其起源于优先归巢至眼眶组织和皮下组织的B细胞亚群。
