含TCGF/IL-2制剂的肿瘤抑制作用。
Tumour inhibitory effects of TCGF/IL-2/-containing preparations.
作者信息
Bubeník J, Indrová M, Perlmann P, Berzins K, Mach O, Kraml J, Toulcová A
出版信息
Cancer Immunol Immunother. 1985;19(1):57-61. doi: 10.1007/BF00199313.
Abstract
Supernatants from ConA-stimulated rat spleen cell cultures and from cultures of PMA-stimulated murine lymphoma subline EL-4TF were found to contain TCGF and to inhibit growth of a transplantable, MC-induced sarcoma MC11 in syngeneic mice. Tumour-inhibitory effects of the supernatants were dependent on local and repeated administration. Prior to use of the supernatants obtained from PMA-stimulated EL-4TF cell cultures, the dialysable PMA had to be removed; contamination with PMA was found to abolish the tumour-inhibitory effect of the supernatants and to produce enhancement of tumour growth. A significant tumour-inhibitory effect has also been obtained with partially purified TCGF prepared from culture supernatants of cloned EL-4TF cells by ammonium sulphate precipitation, ion-exchange (FPLC) chromatography, and AcA 44 Ultrogel filtration.
摘要
发现来自刀豆蛋白A刺激的大鼠脾细胞培养物以及佛波酯刺激的小鼠淋巴瘤亚系EL-4TF培养物的上清液含有白细胞介素-2，并能抑制同基因小鼠中一种可移植的、甲基胆蒽诱导的肉瘤MC11的生长。上清液的肿瘤抑制作用取决于局部和重复给药。在使用从佛波酯刺激的EL-4TF细胞培养物获得的上清液之前，必须去除可透析的佛波酯；发现佛波酯污染会消除上清液的肿瘤抑制作用并导致肿瘤生长增强。通过硫酸铵沉淀、离子交换（快速蛋白质液相色谱）色谱法和AcA 44琼脂糖凝胶过滤从克隆的EL-4TF细胞培养上清液中制备的部分纯化白细胞介素-2也获得了显著的肿瘤抑制作用。
相似文献
1
Tumour inhibitory effects of TCGF/IL-2/-containing preparations.含TCGF/IL-2制剂的肿瘤抑制作用。
Cancer Immunol Immunother. 1985;19(1):57-61. doi: 10.1007/BF00199313.
2
Growth inhibition of an MC-induced mouse sarcoma by TCGF (IL 2)-containing preparations. Preliminary report.含TCGF（白细胞介素2）制剂对MC诱导的小鼠肉瘤的生长抑制作用。初步报告。
Cancer Immunol Immunother. 1983;14(3):205-6. doi: 10.1007/BF00205362.
3
4
Immunotherapy of murine sarcomas with interleukin 2. I. Local administration of human recombinant IL-2 preparations.用白细胞介素2对小鼠肉瘤进行免疫治疗。I. 人重组白细胞介素2制剂的局部给药。
Folia Biol (Praha). 1986;32(6):384-91.
5
The anti-tumour efficacy of human recombinant interleukin 2. Correlation between sensitivity of tumours to the cytolytic effect of LAK cells in vitro and their susceptibility to interleukin 2 immunotherapy in vivo.人重组白细胞介素2的抗肿瘤疗效。肿瘤在体外对淋巴因子激活的杀伤细胞（LAK细胞）细胞溶解作用的敏感性与其在体内对白介素2免疫治疗的敏感性之间的相关性。
Cancer Immunol Immunother. 1987;24(3):269-71. doi: 10.1007/BF00205642.
6
[Effects of TCGF (T-cell growth factor) on experimental malignant glioma-specific killer T-cell].[TCGF（T细胞生长因子）对实验性恶性胶质瘤特异性杀伤性T细胞的作用]
No Shinkei Geka. 1984 Feb;12(2):141-50.
7
Local treatment with human recombinant interleukin 2 inhibits growth of MC-induced sarcomas in syngeneic mice.
Folia Biol (Praha). 1986;32(3):209-11.
8
Anti-tumour efficacy of IL-1 and IL-2.
Folia Biol (Praha). 1988;34(1):42-7.
9
10
Increase in sensitivity of the microcytotoxicity assay by T cell growth factor (IL-2)-containing preparations.
Folia Biol (Praha). 1984;30(1):43-9.
引用本文的文献
1
Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface.Ab-IL2 融合蛋白通过将 CD25 极化到靶细胞-效应细胞界面来介导 NK 细胞免疫突触的形成。
Cancer Immunol Immunother. 2011 Dec;60(12):1789-800. doi: 10.1007/s00262-011-1072-9. Epub 2011 Jul 27.
2
A B-cell lymphoma vaccine using a depot formulation of interleukin-2 induces potent antitumor immunity despite increased numbers of intratumoral regulatory T cells.一种使用白细胞介素-2 储库制剂的 B 细胞淋巴瘤疫苗，尽管肿瘤内调节性 T 细胞数量增加，但仍能诱导强烈的抗肿瘤免疫。
Cancer Immunol Immunother. 2010 Apr;59(4):519-27. doi: 10.1007/s00262-009-0768-6. Epub 2009 Sep 19.
3
Local therapy of cancer with free IL-2.使用游离白细胞介素-2对癌症进行局部治疗。
Cancer Immunol Immunother. 2008 Jul;57(7):931-50. doi: 10.1007/s00262-008-0455-z.
4
Local cytokine treatment of HPV16-associated tumours results in inhibition of their lung metastases.对人乳头瘤病毒16型相关肿瘤进行局部细胞因子治疗可抑制其肺转移。
Clin Exp Metastasis. 2000;18(7):581-7. doi: 10.1023/a:1011987206008.
5
Interleukin-2 gene therapy of residual EL-4 leukaemia potentiates the effect of cyclophosphamide pretreatment.白细胞介素-2基因疗法治疗残留的EL-4白血病可增强环磷酰胺预处理的效果。
J Cancer Res Clin Oncol. 1995;121(1):39-43. doi: 10.1007/BF01202727.
6
The anti-tumour efficacy of human recombinant interleukin 2. Correlation between sensitivity of tumours to the cytolytic effect of LAK cells in vitro and their susceptibility to interleukin 2 immunotherapy in vivo.人重组白细胞介素2的抗肿瘤疗效。肿瘤在体外对淋巴因子激活的杀伤细胞（LAK细胞）细胞溶解作用的敏感性与其在体内对白介素2免疫治疗的敏感性之间的相关性。
Cancer Immunol Immunother. 1987;24(3):269-71. doi: 10.1007/BF00205642.
7
In vivo augmentation of the cytotoxicity of spleen lymphocytes against syngeneic B-16 melanoma cells and the suppression of the artificial metastases in C57BL/6 mice by subcutaneous multiple injections of high dose human recombinant interleukin-2 (rIL-2).通过皮下多次注射高剂量人重组白细胞介素-2（rIL-2），在体内增强C57BL/6小鼠脾淋巴细胞对同基因B-16黑色素瘤细胞的细胞毒性，并抑制人工转移。
J Cancer Res Clin Oncol. 1986;111(3):182-6. doi: 10.1007/BF00389231.
8
Local interleukin-2 therapy in bovine ocular squamous cell carcinoma. A pilot study.牛眼鳞状细胞癌的局部白细胞介素-2治疗。一项试点研究。
Cancer Immunol Immunother. 1989;30(3):165-9. doi: 10.1007/BF01669425.
9
Therapeutic efficacy of human recombinant interleukin-2 (TGP-3) alone or in combination with cyclophosphamide and immunocompetent cells in allogeneic, semi-syngeneic, and syngeneic murine tumors.人重组白细胞介素-2（TGP-3）单独或与环磷酰胺及免疫活性细胞联合应用于同种异体、半同基因和同基因小鼠肿瘤的治疗效果。
Cancer Immunol Immunother. 1989;30(2):71-80. doi: 10.1007/BF01665956.
10
Local and regional immunotherapy of cancer with interleukin 2.白细胞介素2对癌症的局部和区域免疫治疗
J Cancer Res Clin Oncol. 1990;116(1):1-7. doi: 10.1007/BF01612631.
本文引用的文献
1
Passive immunity in mice against C57BL leukosis E.L. 4 by means of iso-immune serum.通过同种免疫血清使小鼠获得针对C57BL白血病E.L. 4的被动免疫。
Cancer Res. 1956 May;16(4):338-43.
2
Fast protein liquid chromatography of pyridoxalated and glutaraldehyde-treated human haemoglobin.
J Chromatogr. 1982 Nov 19;249(2):403-4. doi: 10.1016/s0021-9673(00)86352-9.
3
Continuous cytotoxic T-cell lines.
Contemp Top Immunobiol. 1980;11:139-55. doi: 10.1007/978-1-4684-3701-0_4.
4
5
T-cell growth factor.T细胞生长因子。
Immunol Rev. 1980;51:337-57. doi: 10.1111/j.1600-065x.1980.tb00327.x.
6
Clearance of interleukin 2 from the blood of normal and T cell-depleted mice.正常小鼠和T细胞耗竭小鼠血液中白细胞介素2的清除情况。
Eur J Immunol. 1982 Nov;12(11):983-5. doi: 10.1002/eji.1830121117.
7
Purification of human interleukin 2 to apparent homogeneity and its molecular heterogeneity.人白细胞介素2的纯化至表观均一性及其分子异质性
J Exp Med. 1982 Aug 1;156(2):454-64. doi: 10.1084/jem.156.2.454.
8
Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2.通过体内给予纯化的白细胞介素2增强长期培养的T淋巴细胞的抗肿瘤治疗效果。
J Exp Med. 1982 Apr 1;155(4):968-80. doi: 10.1084/jem.155.4.968.
9
Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity.小鼠T细胞生长因子的纯化。一种具有辅助活性的淋巴细胞有丝分裂原。
J Exp Med. 1981 Aug 1;154(2):422-31. doi: 10.1084/jem.154.2.422.
10
Properties of sodium dodecyl sulfate-denatured Interleukin 2.十二烷基硫酸钠变性白细胞介素2的特性
J Immunol. 1981 Apr;126(4):1351-4.
Zotero 插件