Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan.
Arch Virol. 2024 May 9;169(5):116. doi: 10.1007/s00705-024-06051-1.
In this study, we investigated the role of serum/glucocorticoid-regulated kinase 1 (SGK1) in varicella-zoster virus (VZV) replication. VZV DNA replication and plaque formation were inhibited by SGK1 knockout and treatment with an SGK1 inhibitor. Furthermore, SGK1 inhibition suppressed the increase in cyclin B1 expression induced by VZV infection. These results suggest that VZV infection induces SGK1 activation, which is required for efficient viral proliferation through the expression of cyclin B1. This is the first study to report that SGK1 is involved in the VZV life cycle.
在这项研究中，我们研究了血清/糖皮质激素调节激酶 1（SGK1）在水痘-带状疱疹病毒（VZV）复制中的作用。通过敲除 SGK1 和使用 SGK1 抑制剂处理，抑制了 VZV DNA 复制和蚀斑形成。此外，SGK1 抑制抑制了 VZV 感染诱导的细胞周期蛋白 B1 表达增加。这些结果表明，VZV 感染诱导 SGK1 激活，这是通过表达细胞周期蛋白 B1 促进病毒增殖所必需的。这是第一项报道 SGK1 参与 VZV 生命周期的研究。
