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血清和糖皮质激素调节激酶 1 对于甲型流感病毒核糖核蛋白的核输出是必需的。

Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus.

机构信息

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

出版信息

J Virol. 2013 May;87(10):6020-6. doi: 10.1128/JVI.01258-12. Epub 2013 Mar 13.

DOI:10.1128/JVI.01258-12
PMID:23487453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3648197/
Abstract

We previously performed a small interfering RNA (siRNA) screen and identified serum- and glucocorticoid-regulated kinase 1 (SGK1) as a host factor required for influenza A virus replication. However, the role of SGK1 in the influenza viral life cycle has never been examined. In this study, we demonstrate that SGK1 is required for optimal replication of influenza virus, using the SGK1 inhibitor GSK 650394 and SGK1-specific siRNAs. We also demonstrate that SGK1 is required for viral ribonucleoprotein nuclear export.

摘要

我们之前进行了小干扰 RNA (siRNA) 筛选，发现血清和糖皮质激素调节激酶 1 (SGK1) 是流感病毒复制所必需的宿主因子。然而，SGK1 在流感病毒生命周期中的作用从未被研究过。在这项研究中，我们使用 SGK1 抑制剂 GSK 650394 和 SGK1 特异性 siRNA 证明了 SGK1 是流感病毒最佳复制所必需的。我们还证明了 SGK1 是病毒核糖核蛋白核输出所必需的。

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Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression.血清和糖皮质激素调节激酶 1（SGK1）在乳腺癌中的激活：需要 mTORC1 活性与 ER-α表达相关。
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