乌拉坦麻醉大鼠额叶皮质中与条件作用相关的单单位活动。

Conditioning-related single unit activity in the frontal cortex of urethane anesthetized rats.

作者信息

Pirch J H, Corbus M J, Rigdon G C

出版信息

Int J Neurosci. 1985 Jan;25(3-4):263-71. doi: 10.3109/00207458508985379.

DOI:10.3109/00207458508985379

Abstract

Responses of frontal cortex single units to a tone preceding medial forebrain bundle (MFB) stimulation were recorded in urethane anesthetized rats. The animals were implanted with monopolar electrodes for MFB stimulation and, following recovery, stimulation parameters which supported self-stimulation were determined for each rat. Prior to the unit recording experiment, the animals were trained to associate a 2-sec tone with MFB stimulation. Trials were presented at variable intervals. Under urethane anesthesia, single units were isolated and the responses of units to paired and unpaired tones were determined. The results indicate that conditioning-related responses of frontal cortex single units can be recorded in urethane anesthetized rats.

摘要

在氨基甲酸乙酯麻醉的大鼠中记录了额叶皮质单个神经元对内侧前脑束（MFB）刺激之前一个音调的反应。给动物植入用于MFB刺激的单极电极，恢复后，为每只大鼠确定支持自我刺激的刺激参数。在进行神经元记录实验之前，训练动物将2秒的音调与MFB刺激联系起来。试验以可变的间隔进行。在氨基甲酸乙酯麻醉下，分离出单个神经元，并确定神经元对配对和未配对音调的反应。结果表明，在氨基甲酸乙酯麻醉的大鼠中可以记录到额叶皮质单个神经元与条件反射相关的反应。