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绵羊的胎儿编程:对繁殖和生产的影响

Foetal programming in sheep: Reproductive and productive implications.

作者信息

Barcellos Júlio Otávio Jardim, Zago Daniele, Fagundes Helena Xavier, Pereira Gabriel Ribas, Sartori Everton Dezordi

机构信息

Federal University of Rio Grande do Sul - Department of Animal Science, Porto Alegre, Brazil.

Federal University of Rio Grande do Sul - Department of Animal Science, Porto Alegre, Brazil.

出版信息

Anim Reprod Sci. 2024 Jun;265:107494. doi: 10.1016/j.anireprosci.2024.107494. Epub 2024 May 7.

DOI:10.1016/j.anireprosci.2024.107494
PMID:38723401
Abstract

The aim of this study was to evaluate the effects of pregnant ewe nutrition on the performance of offspring in terms of meat, wool production, and reproduction. Foetal programming in sheep has focused on several aspects related to foetal growth, postnatal production, behaviour, and immunological performance. Currently, significant efforts are being made to understand the endocrine, metabolic, and epigenetic mechanisms involved in offspring development. Current studies have not only evaluated the foetal period, despite the pre-conception parental nutrition has demonstrated an effect on the foetal, embryonic, and pre-implantation periods and can generate permanent effects in the foetal and postnatal phases. The performance of offspring is the result of interactions between the genome, epigenome, and environmental interventions during conception. Several factors influence the expression of phenotypic characteristics in progenies; however, this study focused on presenting data on the effect of pregnant ewe nutrition alone on foetal growth and the productive aspects of their offspring.

摘要

本研究的目的是评估怀孕母羊营养对后代在肉类、羊毛生产和繁殖性能方面的影响。绵羊的胎儿编程聚焦于与胎儿生长、产后生产、行为和免疫性能相关的几个方面。目前,人们正在做出巨大努力来了解参与后代发育的内分泌、代谢和表观遗传机制。尽管孕前亲本营养已被证明对胎儿期、胚胎期和植入前期有影响,并可在胎儿期和产后阶段产生永久性影响,但目前的研究不仅评估了胎儿期。后代的表现是受孕期间基因组、表观基因组和环境干预之间相互作用的结果。有几个因素影响后代表型特征的表达;然而,本研究重点在于呈现关于怀孕母羊营养单独对胎儿生长及其后代生产方面影响的数据。

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