Sher M R, Schultz J S, Ragsdale C G, Kapur J J, Sullivan D B, Cassidy J T
J Rheumatol. 1985 Feb;12(1):114-8.
Significant HLA-DR and MT associations were observed with certain clinical and serologic manifestations of pauciarticular onset juvenile rheumatoid arthritis (PO-JRA). An increase in the MTI frequency was found in 56 children with PO-JRA in comparison to 95 normal controls. This association was limited to children with a younger age of onset (less than 6 years) and a persistent pauciarticular course. An increase in HLA-DRW8 and a decrease in DR4 were associated with a younger age of onset and antinuclear antibody (ANA) seropositivity. In addition, an increased frequency of DR5 was seen in ANA positive children. All of these HLA-DR and MT associations were independent of coassociating Ia specificities.
观察到HLA - DR和MT与少关节型幼年类风湿性关节炎（PO - JRA）的某些临床和血清学表现之间存在显著关联。与95名正常对照相比，在56名PO - JRA儿童中发现MTI频率增加。这种关联仅限于发病年龄较小（小于6岁）且病程持续为少关节型的儿童。HLA - DRW8增加和DR4减少与发病年龄较小及抗核抗体（ANA）血清阳性相关。此外，在ANA阳性儿童中观察到DR5频率增加。所有这些HLA - DR和MT关联均独立于共同关联的Ia特异性。
