Friis J, Morling N, Pedersen F K, Heilmann C, Jørgensen B, Svejgaard A, Thomsen K
J Rheumatol. 1985 Feb;12(1):119-22.
The prevalence of HLA-B27 in 88 patients with juvenile chronic arthritis was 22/88 (25%) with little variation among the 3 commonly recognized onset types. This was significantly more frequent than the prevalence of 9.4% in a Danish reference population. A strong association was found between the HLA-B27 antigen and 3 subgroups of patients: (1) boys with pauciarticular and late onset disease; (2) girls with apophyseal joint fusion; (3) a group of patients in whom the clinical picture was compatible with reactive arthritis or incomplete Reiter's syndrome. When these 3 subgroups were excluded from the total patient population, only 8 of the remaining 63 patients carried the B27 antigen, i.e., 13%, which was not significantly different from the prevalence in the reference population. Thus, the 3 subgroups account completely for the increase of B27 in the entire group of patients.
88例青少年慢性关节炎患者中HLA - B27的阳性率为22/88（25%），在3种常见的发病类型中差异不大。这明显高于丹麦参照人群9.4%的阳性率。发现HLA - B27抗原与3组患者之间存在强关联：（1）少关节型和晚发型疾病的男孩；（2）有骨骺关节融合的女孩；（3）临床表现符合反应性关节炎或不完全型赖特综合征的一组患者。当从全部患者人群中排除这3个亚组后，其余63例患者中只有8例携带B27抗原，即13%，这与参照人群的阳性率无显著差异。因此，这3个亚组完全解释了整个患者组中B27阳性率的升高。
