National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
National Biobank of Thailand, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
J Antibiot (Tokyo). 2024 Jul;77(7):422-427. doi: 10.1038/s41429-024-00733-3. Epub 2024 May 9.
Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodehyde E (3). 9-Methoxystrobilurin derivatives 1 and 2 exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC values of 0.12 and 0.21 μM, respectively.
调查担子菌 Favolaschia minutissima TBRC-BCC 19434 的培养物导致了两种未描述的β-甲氧基丙烯酸盐代谢物，9-甲氧基strobilurin R（1）和 S（2），以及一种降解的醛衍生物，favodehyde E（3）的分离。9-甲氧基strobilurin 衍生物 1 和 2 对恶性疟原虫 K1（多药耐药株）表现出显著的抗疟活性，IC 值分别为 0.12 和 0.21 μM。
