Mental Health Research Center, Moscow, Russia.
Bull Exp Biol Med. 2024 Mar;176(5):585-590. doi: 10.1007/s10517-024-06072-5. Epub 2024 May 9.
Leukocyte elastase is a marker of inflammation. Previously, a relationship was found between the severity of mental disorders in patients and elastase-like activity of blood plasma. The effect of various neurotropic drugs on leukocyte elastase activity was analyzed in an in vitro experiment. We revealed an inhibitory effect of the benzodiazepine tranquilizers diazepam and bromodihydrochlorophenylbenzodiazepine and immunomodulators aminodihydrophthalazinedione and diclofenac on the plasma elastase-like activity of healthy donors and pure human neutrophil elastase. The antipsychotics chlorpromazine and alimemazine, as well as the nootropic vinpocetine increased elastase-like activity in a dose-dependent manner. The activating effect of chlorpromazine and vinpocetine, but not alimemazine, was reproduced in neutrophil elastase. We hypothesized that these drugs can affect the development of inflammatory reactions in the complex therapy of mental disorders.
白细胞弹性蛋白酶是炎症的标志物。先前发现，患者精神障碍的严重程度与血浆弹性酶样活性之间存在关系。在体外实验中分析了各种神经递质药物对白细胞弹性酶活性的影响。我们发现苯二氮䓬类镇静剂地西泮和溴二氢氯苯二氮䓬以及免疫调节剂氨基二氢邻苯二嗪酮和双氯芬酸对健康供体和纯人中性粒细胞弹性蛋白酶的血浆弹性酶样活性具有抑制作用。抗精神病药氯丙嗪和阿利马嗪以及益智药长春西汀呈剂量依赖性增加弹性酶样活性。氯丙嗪和长春西汀而非阿利马嗪的激活作用在中性粒细胞弹性蛋白酶中重现。我们假设这些药物可以影响精神障碍的综合治疗中的炎症反应的发展。
