Mental Health Research Center, Moscow, Russia.
Mental Health Research Center, Moscow, Russia.
Exp Gerontol. 2021 Jul 1;149:111329. doi: 10.1016/j.exger.2021.111329. Epub 2021 Mar 27.
Aging is associated with a decline in the erectile capacity and sexual motivation. Emerging new therapy for the treatment of these age-related pathologies in men is the use of the regulatory peptides. We validated the use of HLDF-6-amide (Thr-Gly-Glu-Hse-His-Arg-NH2) as a potential modulator of sexual performance in aged male rats. Behavioral tests, including the standard parameters of sexual behavior, were performed longitudinally at 20 and 26 months of age. The effects of HLDF-6-amide administered daily at 300 μg/kg for 3 week on the levels of sex hormones and the activity of antioxidant enzymes and indicators of inflammation were evaluated. HLDF-6-amide administration increased the copulative activity of the 20-month-old male rats. This effect of HLDF-6-amide was more pronounced in the 26-month-old rats. Although HLDF-6-amide did not have the effect on the levels of circulating testosterone and estradiol, it reduced the activity of leukocyte elastase and glutathione-S-peroxidase, suggesting that the peptide has anti-inflammatory and antioxidant properties. Therefore, this study shows that HLDF-6-amide has the positive impact on sexual activity in this rodent model, representing a new therapeutic approach for improving sexual performance in older men.
衰老是与勃起能力和性动力下降相关的。对于男性与年龄相关的这些病理变化的新兴治疗方法是使用调节肽。我们验证了 HLDF-6-酰胺（Thr-Gly-Glu-Hse-His-Arg-NH2）作为一种潜在的调节剂，可用于改善老年雄性大鼠的性表现。进行了行为测试，包括性行为的标准参数，在 20 个月和 26 个月时进行了纵向测试。评估了 HLDF-6-酰胺每天 300μg/kg 给药 3 周对性激素水平、抗氧化酶活性和炎症指标的影响。HLDF-6-酰胺给药增加了 20 月龄雄性大鼠的交配活动。HLDF-6-酰胺在 26 月龄大鼠中的这种作用更为明显。尽管 HLDF-6-酰胺对循环睾酮和雌二醇水平没有影响，但它降低了白细胞弹性蛋白酶和谷胱甘肽-S-过氧化物酶的活性，表明该肽具有抗炎和抗氧化特性。因此，这项研究表明，HLDF-6-酰胺对啮齿动物模型中的性活动有积极影响，为改善老年男性的性表现提供了一种新的治疗方法。
