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ACG Case Rep J. 2024 May 9;11(5):e01360. doi: 10.14309/crj.0000000000001360. eCollection 2024 May.
2
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Front Immunol. 2022 Oct 31;13:957575. doi: 10.3389/fimmu.2022.957575. eCollection 2022.
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本文引用的文献

1
Anti-NMDAR encephalitis in Crohn's disease undergoing long-term infliximab treatment: A case report.克罗恩病患者在长期接受英夫利昔单抗治疗后出现抗 NMDAR 脑炎：病例报告。
Front Immunol. 2022 Oct 31;13:957575. doi: 10.3389/fimmu.2022.957575. eCollection 2022.
2
Anti-NMDA receptor encephalitis: a review of mechanistic studies.抗N-甲基-D-天冬氨酸受体脑炎：机制研究综述
Int J Physiol Pathophysiol Pharmacol. 2021 Feb 15;13(1):1-11. eCollection 2021.
3
NMDAR antibody encephalitis overlapping with CLIPPERS syndrome in a psoriasis patient on adalimumab.一名使用阿达木单抗治疗的银屑病患者出现与CLIPPERS综合征重叠的NMDAR抗体脑炎。
J Neurol. 2021 Feb;268(2):714-716. doi: 10.1007/s00415-020-10341-4. Epub 2021 Jan 2.
4
Autoimmune Encephalitis During Treatment With Adalimumab: A Case Report in Crohn's Disease.阿达木单抗治疗期间的自身免疫性脑炎：克罗恩病的一例报告
Inflamm Bowel Dis. 2021 Mar 15;27(4):e40-e41. doi: 10.1093/ibd/izaa302.
5
Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events.肿瘤坏死因子抑制剂暴露与炎症性中枢神经系统事件的关联。
JAMA Neurol. 2020 Aug 1;77(8):937-946. doi: 10.1001/jamaneurol.2020.1162.
6
Autoimmune Encephalitis: NMDA Receptor Encephalitis as an Example of Translational Neuroscience.自身免疫性脑炎：以 NMDA 受体脑炎为例的转化神经科学。
Neurotherapeutics. 2020 Apr;17(2):404-413. doi: 10.1007/s13311-020-00861-2.
7
Anti-N-methyl-D-aspartate receptor encephalitis during treatment with adalimumab for psoriasis.阿达木单抗治疗银屑病期间发生的抗N-甲基-D-天冬氨酸受体脑炎
J Eur Acad Dermatol Venereol. 2020 Oct;34(10):e591-e593. doi: 10.1111/jdv.16456. Epub 2020 May 19.
8
Anti-TNF Therapy in Crohn's Disease.抗 TNF 治疗克罗恩病。
Int J Mol Sci. 2018 Jul 31;19(8):2244. doi: 10.3390/ijms19082244.
9
Anti-NMDAR encephalitis in a patient with Crohn disease receiving adalimumab.一名接受阿达木单抗治疗的克罗恩病患者发生抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎。
Neurol Neuroimmunol Neuroinflamm. 2018 Jul 2;5(5):e476. doi: 10.1212/NXI.0000000000000476. eCollection 2018 Sep.
10
Autoimmune diseases induced by biological agents. A review of 12,731 cases (BIOGEAS Registry).生物制剂诱发的自身免疫性疾病。对12731例病例的回顾（BIOGEAS注册研究）
Expert Opin Drug Saf. 2017 Nov;16(11):1255-1271. doi: 10.1080/14740338.2017.1372421. Epub 2017 Sep 7.

克罗恩病长期使用阿达木单抗治疗期间出现抗甲基-D受体脑炎

Anti--Methyl-D Receptor Encephalitis During Long-Term Adalimumab Therapy for Crohn's Disease.

作者信息

MacKay Scott, Salh Baljinder

机构信息

Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

ACG Case Rep J. 2024 May 9;11(5):e01360. doi: 10.14309/crj.0000000000001360. eCollection 2024 May.

DOI:10.14309/crj.0000000000001360
PMID:38725477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11081562/
Abstract

A 46-year-old woman with fistulizing Crohn's disease in clinical remission in the setting of long-term adalimumab therapy presented to hospital and was ultimately diagnosed with anti--methyl-D (NMDA) receptor antibody-mediated autoimmune encephalitis (NMDAr-AE). Inflammatory central nervous system and antibody-mediated adverse effects have been found to be associated with anti-tumor necrosis factor agents, with 5 previous case reports noting cases of NMDAr-AE in patients on these medications. The current article reports this case, which is unique for the length of adalimumab therapy before this presentation, as well as a summary of literature regarding anti-tumor necrosis factors and NMDAr-AE.

摘要

一名46岁患有瘘管性克罗恩病的女性，在长期使用阿达木单抗治疗处于临床缓解期时入院，最终被诊断为抗N-甲基-D-天冬氨酸（NMDA）受体抗体介导的自身免疫性脑炎（NMDAr-AE）。已发现炎症性中枢神经系统和抗体介导的不良反应与抗肿瘤坏死因子药物有关，之前有5例病例报告指出使用这些药物的患者出现NMDAr-AE。本文报告了该病例，其因在此次发病前使用阿达木单抗治疗的时间之长而独特，同时还总结了关于抗肿瘤坏死因子与NMDAr-AE的文献。