真菌病原体中新兴的抗真菌耐药性
Emerging Antifungal Resistance in Fungal Pathogens.
作者信息
Hui Sui Ting, Gifford Hugh, Rhodes Johanna
机构信息
MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
出版信息
Curr Clin Microbiol Rep. 2024;11(2):43-50. doi: 10.1007/s40588-024-00219-8. Epub 2024 Mar 18.
Abstract
PURPOSE OF REVIEW
Over recent decades, the number of outbreaks caused by fungi has increased for humans, plants (including important crop species) and animals. Yet this problem is compounded by emerging antifungal drug resistance in pathogenic species. Resistance develops over time when fungi are exposed to drugs either in the patient or in the environment.
RECENT FINDINGS
Novel resistant variants of fungal pathogens that were previously susceptible are evolving (such as ) as well as newly emerging fungal species that are displaying antifungal resistance profiles (e.g. and ).
SUMMARY
This review highlights the important topic of emerging antifungal resistance in fungal pathogens and how it evolved, as well as how this relates to a growing public health burden.
摘要
综述目的
在最近几十年中，由真菌引起的人类、植物（包括重要农作物品种）和动物疫情数量有所增加。然而，致病物种中不断出现的抗真菌药物耐药性使这一问题更加复杂。当真菌在患者体内或环境中接触药物时，耐药性会随着时间的推移而产生。
最新发现
以前敏感的真菌病原体正在进化出新的耐药变体（如 ），同时新出现的真菌物种也呈现出抗真菌耐药性特征（如 和 ）。
总结
本综述强调了真菌病原体中新兴抗真菌耐药性这一重要主题，以及它是如何演变的，以及这与日益增加的公共卫生负担之间的关系。
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