Chandramouli Manasa, Basavanna Vrushabendra, Ningaiah Srikantamurthy
Department of Chemistry, Vidyavardhaka College of Engineering Visvesvaraya Technological University Mysore Karnataka India.
Aging Med (Milton). 2024 Apr 9;7(2):231-238. doi: 10.1002/agm2.12301. eCollection 2024 Apr.
Circadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer. Human pathologies alter circadian clock gene expression, and transgenic rats with clock gene defects progress to cancer and age prematurely. In the growth of age-linked pathologies and carcinogenesis, cell proliferation and genome integrity play critical roles. The relationship concerning the cell cycle regulation and circadian clock is discussed in this article. The circadian clock controls the behavior and countenance of many main cell cycle and cell cycle check-point proteins, and cell cycle-associated proteins, in turn, control the activity and expression of circadian clock proteins. The circadian clock can be reset by DNA disruption, providing a molecular mechanism for mutual control amid the cell cycle and the clock. This circadian clock-dependent regulation of cell proliferation, composed with other circadian clock-dependent physiological functions including metabolism control, genotoxic and oxidative stress response, and DNA repair, unlocks new avenues for studying the processes of aging and carcinogenesis.
昼夜节律是由昼夜节律调节因子引起的生理和行为振荡。隐花色素、周期蛋白和脑和肌肉ARNT样蛋白1（Bmal1）是与衰老和癌症相关的昼夜节律时钟基因。人类病理学改变昼夜节律时钟基因的表达，具有时钟基因缺陷的转基因大鼠会发展成癌症并过早衰老。在与年龄相关的病理学发展和致癌过程中，细胞增殖和基因组完整性起着关键作用。本文讨论了细胞周期调控与昼夜节律时钟之间的关系。昼夜节律时钟控制许多主要细胞周期和细胞周期检查点蛋白以及细胞周期相关蛋白的行为和面容，反过来，细胞周期相关蛋白控制昼夜节律时钟蛋白的活性和表达。昼夜节律时钟可以通过DNA破坏而重置，这为细胞周期和时钟之间的相互控制提供了一种分子机制。这种由昼夜节律时钟依赖性调节的细胞增殖，与包括代谢控制、遗传毒性和氧化应激反应以及DNA修复在内的其他昼夜节律时钟依赖性生理功能相结合，为研究衰老和致癌过程开辟了新途径。
