Jaffar Hafiza Madiha, Al-Asmari Fahad, Khan Faima Atta, Rahim Muhammad Abdul, Zongo Eliasse
University Institute of Diet & Nutritional Sciences, Faculty of Allied Health Sciences The University of Lahore Lahore Pakistan.
Department of Food and Nutrition Sciences, College of Agricultural and Food Sciences King Faisal University Al-Ahsa Saudi Arabia.
Food Sci Nutr. 2024 Feb 16;12(5):3097-3111. doi: 10.1002/fsn3.4010. eCollection 2024 May.
Liver diseases, encompassing conditions such as cirrhosis, present a substantial global health challenge with diverse etiologies, including viral infections, alcohol consumption, and non-alcoholic fatty liver disease (NAFLD). The exploration of natural compounds as therapeutic agents has gained traction, notably the herbal remedy milk thistle (), with its active extract, silymarin, demonstrating remarkable antioxidant and hepatoprotective properties in extensive preclinical investigations. It can protect healthy liver cells or those that have not yet sustained permanent damage by reducing oxidative stress and mitigating cytotoxicity. Silymarin, a natural compound with antioxidant properties, anti-inflammatory effects, and antifibrotic activity, has shown potential in treating liver damage caused by alcohol, NAFLD, drug-induced toxicity, and viral hepatitis. Legalon® is a top-rated medication with excellent oral bioavailability, effective absorption, and therapeutic effectiveness. Its active component, silymarin, has antioxidant and hepatoprotective properties, Eurosil 85® also, a commercial product, has lipophilic properties enhanced by special formulation processes. Silymarin, during clinical trials, shows potential improvements in liver function, reduced mortality rates, and alleviation of symptoms across various liver disorders, with safety assessments showing low adverse effects. Overall, silymarin emerges as a promising natural compound with multifaceted hepatoprotective properties and therapeutic potential in liver diseases.
肝脏疾病，包括肝硬化等病症，由于多种病因，如病毒感染、酒精摄入和非酒精性脂肪性肝病（NAFLD），在全球范围内构成了重大的健康挑战。探索天然化合物作为治疗药物已受到关注，尤其是草药水飞蓟，其活性提取物水飞蓟素在广泛的临床前研究中显示出显著的抗氧化和肝脏保护特性。它可以通过减少氧化应激和减轻细胞毒性来保护健康的肝细胞或尚未遭受永久性损伤的细胞。水飞蓟素是一种具有抗氧化特性、抗炎作用和抗纤维化活性的天然化合物，已显示出治疗由酒精、NAFLD、药物诱导的毒性和病毒性肝炎引起的肝损伤的潜力。利加隆®是一种一流的药物，具有出色的口服生物利用度、有效吸收和治疗效果。其活性成分水飞蓟素具有抗氧化和肝脏保护特性，同样，商业产品欧水飞蓟素85®通过特殊的制剂工艺增强了亲脂性。在临床试验中，水飞蓟素显示出对各种肝脏疾病的肝功能有潜在改善、死亡率降低和症状缓解，安全性评估显示不良反应较低。总体而言，水飞蓟素是一种有前途的天然化合物，具有多方面的肝脏保护特性和在肝脏疾病中的治疗潜力。
