CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai, Shandong 264003, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Anal Methods. 2024 May 23;16(20):3240-3248. doi: 10.1039/d4ay00263f.
Currently, Nernstian-response-based polymeric membrane potentiometric sensors using molecularly imprinted polymers (MIPs) as receptors have been successfully developed for determination of organic ionic species. However, the preparation of these MIP receptors usually involves tedious and time-consuming template-removal procedures. Herein, a template-removal-free MIP is proposed and used as a receptor for fabrication of a potentiometric sensor. The proposed methodology not only significantly shortens the preparation time of MIP-based potentiometric sensors but also improves the batch-to-batch reproducibility of these sensors. By using antibiotic vancomycin as a model, the new concept offers a linear concentration range of 1.0 × 10 to 1.0 × 10 mol L with a detection limit of 2.51 × 10 mol L. It can be expected that the template-removal-free MIP-based sensing strategy could lay the foundation for simple fabrication of electrochemical sensors without the need for template removal such as potentiometric and capacitive sensors and ion-sensitive field-effect transistors.
目前，基于能斯特响应的聚合物膜电位传感器已成功开发，其使用分子印迹聚合物（MIPs）作为受体，用于测定有机离子物质。然而，这些 MIP 受体的制备通常涉及繁琐且耗时的模板去除过程。本文提出了一种无需模板去除的 MIP，并将其用作制备电位传感器的受体。所提出的方法不仅大大缩短了基于 MIP 的电位传感器的制备时间，而且提高了这些传感器的批间重现性。以抗生素万古霉素为模型，该新方法提供了 1.0×10 到 1.0×10 mol/L 的线性浓度范围，检测限为 2.51×10 mol/L。可以预期，无需模板去除的免模板 MIP 基传感策略可为简单制造电化学传感器奠定基础，例如电位和电容传感器以及离子敏场效应晶体管。
