1,25-二羟基维生素D3和1,24-二羟基维生素D3在体外抑制对T细胞依赖性抗原的抗体反应。

1,25-Dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress in vitro antibody response to T cell-dependent antigen.

作者信息

Komoriya K, Nagata I, Tsuchimoto M, Kunisawa K, Takeshita T, Naruchi T

出版信息

Biochem Biophys Res Commun. 1985 Mar 29;127(3):753-8. doi: 10.1016/s0006-291x(85)80007-3.

Abstract

1,25-Dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppressed an antibody response to sheep red blood cells (SRBC, T cell-dependent antigen) by murine splenocytes, in concentrations ranging from 10(-10)-10(-7)M. These suppressive effects were markedly abrogated when T cell-depleted lymphocytes were cultured in the presence of a supernatant of concanavalin A-stimulated spleen cells. On the contrary, neither of them suppressed antibody response to trinitrophenyl-lipopolysaccharide (T cell-independent antigen). These results suggest that the suppressive effect of active vitamin D3 on anti-SRBC response was mediated by the inhibition of T cells.

摘要

1,25-二羟基维生素D3和1,24-二羟基维生素D3在浓度范围为10^(-10)-10^(-7)M时，可抑制小鼠脾细胞对绵羊红细胞（SRBC，T细胞依赖性抗原）的抗体反应。当在伴刀豆球蛋白A刺激的脾细胞上清液存在的情况下培养去除T细胞的淋巴细胞时，这些抑制作用明显被消除。相反，它们两者均不抑制对三硝基苯基-脂多糖（T细胞非依赖性抗原）的抗体反应。这些结果表明，活性维生素D3对抗SRBC反应的抑制作用是由T细胞的抑制介导的。