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Biological activity of metal complexes. I. Interaction of pt(II), pd(II) and rh(I) complexes with E. coli strains and with mice LS fibroblasts in vitro.

作者信息

Aresta M, Giordano D, Ingrosso A, Riccardi S, Sinigaglia E

出版信息

Chem Biol Interact. 1979;28(1):61-70. doi: 10.1016/0009-2797(79)90114-5.

DOI:10.1016/0009-2797(79)90114-5
PMID:387267
Abstract

The effects of a number of Pt(II, Pd(II) and Rh(I) complexes against cultures of Escherichia coli (strains B, H10178, uvra-, recA-) and cultures of mice LS Fibroblasts were tested. Most of the compounds showed higher cytotoxic activity than the cis-Pt(NH3)2Cl2, the compound at present on clinical trial as antittumour drug. A new model of active compound is proposed.

摘要

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